EC Number   |
General Information |
Reference |
|---|
    2.1.1.4 | evolution |
the enzyme belongs to S-adenosyl-L-methionine dependent animal natural product O-methyltransferase |
734731 |
| 2.1.1.4 | malfunction |
lack of melatonin is a risk signal and will result in diabetes, psychiatric disorders, and other diverse medical conditions |
734731 |
| 2.1.1.4 | malfunction |
melatonin production is significantly reduced or increased when the rice plants overexpressed or suppressed the endogenous rice caffeic acid O-methyltransferase |
734389 |
| 2.1.1.4 | malfunction |
transgenic rice plants overexpressing rice caffeic acid O-methyltransferase/N-acetylserotonin O-methyltransferase show an increase in melatonin levels whereas transgenic rice plants suppressing the rice caffeic acid O-methyltransferase/N-acetylserotonin O-methyltransferase have a significant decrease on melatonin levels |
734389 |
| 2.1.1.4 | metabolism |
all three isozymes are involved in the biosynthesis of melatonin. the enzyme is involved in a general tryptophan metabolism pathway where it catalyzes the final reaction in the production of melatonin, converting normelatonin to melatonin (a neurohormone). The conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate in the same pathway is also catalyzed by this enzyme. In general tryptophan metabolism pathway, tryptophan functions as a biochemical precursor for serotonin |
734508 |
| 2.1.1.4 | metabolism |
ASMT is a key enzyme to catalyse the terminal step of melatonin (N-acetyl-5-methoxytryptamine) |
734731 |
| 2.1.1.4 | metabolism |
HIOMT is a key enzyms involved in melatonin synthesis |
703589 |
| 2.1.1.4 | metabolism |
in vivo role played by the COMT for biosynthesizing melatonin |
-, 734548 |
| 2.1.1.4 | metabolism |
last enzyme of the melatonin-synthesis pathway |
705249 |
| 2.1.1.4 | metabolism |
the enzyme catalyzes the conversion of N-acetylserotonin to melatonin as the last step in melatonin biosynthesis. The enzyme exhibits no caffeic acid O-methyltransferase activity, suggesting that its function is highly specific to melatonin synthesis |
-, 734549 |
