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EC Number
Expression
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Reference
2.3.3.5
down
the nitrogen regulator GlnR regulates the methylcitrate cycle through direct repression of the transcription of the prpDBC operon
757102
2.3.3.5
up
the de novo protein SynGltA stimulates the prp operon. SynGltA allows cells to recover from a defect in central carbon and energy metabolism by altering the regulation of an alternative metabolic pathway. Specifically, SynGltA dramatically enhances the expression of prpC, a gene encoding methylcitrate synthase in the propionate degradation pathway. This endogenous protein has promiscuous catalytic activity, which when overexpressed, compensates for the deletion of citrate synthase
755708
2.3.3.5
up
the enzyme is up-regulated during appressorium formation and when grown on propionyl-CoA-producing carbon sources
757708
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