Application | Comment | Organism |
---|---|---|
medicine | upon infection, Trichinella spiralis secretes E2 Ub-conjugating protein UBE2L3, located in the secretory organ of the parasite during the muscle stages of infection. UBE2L3 but specifically binds to a panel of human RING E3 ligases, including the RBR E3 ARIH2 with which it interacts with a higher affinity than the mammalian ortholog UbcH7/UBE2L3. Expression of UBE2L3 in skeletal muscle cells causes a global downregulation in protein ubiquitination, most predominantly affecting motor, sarcomeric and extracellular matrix proteins, thus mediating their stabilization with regards to proteasomal degradation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95376 | isoform ARIH2 | - |