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Literature summary for 2.1.1.4 extracted from
- Hydroxyindole-O-methyltransferase (HIOMT) activity in the retina of melatonin-proficient mice (2019), Heliyon, 5, e02417 .
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | the standard radio-chemical assay is successful for pineal HIOMT only, whereas specific homogenization buffers and HPLC are required to detect retinal activity | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0093 | - |
S-adenosyl-L-methionine | enzyme from pineal gland, pH 7.9, 30°C | Mus musculus |  |
| 0.0098 | - |
S-adenosyl-L-methionine | enzyme from retina, pH 7.9, 30°C | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | D3KU66 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pineal gland | - |
Mus musculus | - |
| retina | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + N-acetylserotonin | - |
Mus musculus | S-adenosyl-L-homocysteine + melatonin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ASMT | - |
Mus musculus |
| HIOMT | - |
Mus musculus |
| hydroxyindole-O-methyltransferase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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