Literature summary for 1.14.11.53 extracted from

Tsuruta, N.; Tsuchihashi, K.; Ohmura, H.; Yamaguchi, K.; Ito, M.; Ariyama, H.; Kusaba, H.; Akashi, K.; Baba, E.
RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells (2020), Biochem. Biophys. Res. Commun., 530, 235-239 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9C0B1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	HCT-116 cells show high expression of both FTO and programmed cell death-ligand 1 (PD-L1) proteins. The knockdown of FTO decreases mRNA and protein levels of PD-L1 in HCT-116 cells. Upon depletion of FTO in HCT-116 cells in the presence of IFN-gamma to upregulate PD-L1 expression, PD-L1 expression is reduced in an IFN-gamma signaling-independent manner. PD-L1 mRNA is m6A-modified and FTO binds to the PD-L1 mRNA in HCT-116 cells	Homo sapiens

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Release 2023.1 (January 2023)