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Information on EC 1.14.11.53 - mRNA N6-methyladenine demethylase

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EC Tree
IUBMB Comments
Contains iron(II). Catalyses oxidative demethylation of mRNA N6-methyladenine. The FTO enzyme from human can also demethylate N3-methylthymine from single stranded DNA and N3-methyluridine from single stranded RNA [1,2] with low activity .
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Word Map
  • 1.14.11.53
  • demethylation
  • demethylases
  • mettl14
  • reader
  • writer
  • erasers
  • ythdf1
  • methyltransferases
  • epitranscriptomic
  • m6a-related
  • fto-mediated
  • m6a-dependent
  • hnrnpa2b1
  • methyltransferase-like
  • hnrnpc
  • lasso
  • m6a-modified
  • igf2bp1
  • merip
  • merip-seq
  • m6a-binding
The enzyme appears in viruses and cellular organisms
Reaction Schemes
N6-methyladenine in mRNA
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+
=
adenine in mRNA
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+
Synonyms
alkbh5, fat mass and obesity-associated protein, alkb homolog 5, alkbh10b, n6-methyladenosine demethylase, m6a rna demethylase, alkbh9b, alkylation repair homolog protein 5, alkbh5 demethylase, rna n6-methyladenine demethylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N6-methyladenine in mRNA + 2-oxoglutarate + O2 = adenine in mRNA + formaldehyde + succinate + CO2
show the reaction diagram
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