2.4.1.B80: alpha-dystroglycan glucuronosyltransferase
This is an abbreviated version!
For detailed information about alpha-dystroglycan glucuronosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.B80
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2.4.1.B80
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muscular
-
dystrophy
-
glycosyltransferase
-
laminin
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dystroglycanopathy
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laminin-binding
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o-mannose
-
matriglycan
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o-mannosylation
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large-dependent
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arenaviruses
-
fukutin
-
fukutin-related
-
mucin-like
-
hypoglycosylation
- 2.4.1.B80
-
muscular
- dystrophy
- glycosyltransferase
- laminin
-
dystroglycanopathy
-
laminin-binding
-
o-mannose
-
matriglycan
-
o-mannosylation
-
large-dependent
- arenaviruses
-
fukutin
-
fukutin-related
-
mucin-like
-
hypoglycosylation
Reaction
Synonyms
LARGE1, like-acetylglucosaminyltransferase
ECTree
2.4.1.B80 alpha-dystroglycan glucuronosyltransferaseAdvanced search results
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General Information on EC 2.4.1.B80 - alpha-dystroglycan glucuronosyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
physiological function
enzyme acts as a bifunctional glycosyltransferase, with both xylosyltransferase and glucuronyltransferase activities, producing repeating units of [3-alpha-D-xylosyl-(1->3)-beta-D-glucuronyl-1-]. LARGE synthesizes the polymer on the O-mannosyl glycan of alpha-dystroglycan in vivo. The LARGE-synthesized, negatively charged glycan on alpha-dystroglycan likely binds to laminin through electrostatic associations with these basic patches
