2.4.1.346: phosphatidyl-myo-inositol dimannoside synthase
This is an abbreviated version!
For detailed information about phosphatidyl-myo-inositol dimannoside synthase, go to the full flat file.
Word Map on EC 2.4.1.346
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2.4.1.346
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mycobacterium
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tuberculosis
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mannosides
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corynebacterium
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lipomannan
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glycolipids
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lipoarabinomannan
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glutamicum
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envelope
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lipoglycans
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smegmatis
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mannosylated
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lm
- 2.4.1.346
- mycobacterium
- tuberculosis
- mannosides
- corynebacterium
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lipomannan
- glycolipids
- lipoarabinomannan
- glutamicum
- envelope
-
lipoglycans
- smegmatis
-
mannosylated
- lm
Reaction
Synonyms
EC 2.4.1.57, GDP-mannose-dependent monoacylated alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase, mannoslytransferase PimB', mannosyltransferase PimB, mannosyltransferase PimB', MgtA, MSMEG_4253, NCgl2106, PimB, pimB', Rv0557, Rv2188c
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General Information
General Information on EC 2.4.1.346 - phosphatidyl-myo-inositol dimannoside synthase
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physiological function
both mannosyltransferases PimA and PimB' (MSMEG_4253) recognize phosphatidyl-myo-inositol as a lipid acceptor. PimA specifically catalyzes the transfer of a mannopyranosyl residue to the 2-position of the myo-inositol ring of phosphatidylinositol, whereas PimB' exclusively transfers to the 6-position. PimB' can catalyze the transfer of a mannopyranosyl residue onto the phosphatidylinositol-monomannoside (PIM1) product of PimA, while PimA is unable in vitro to transfer mannopyranosyl onto the PIM1 product of PimB'
physiological function
characterization of a PimB MgtA double deletion mutant. Gene product of Rv2188c acts as an Ac1PIM1:mannosyltransferase PimB and the product of Rv0557 acts as a GlcAGroAc2:mannosyltransferase MgtA
physiological function
disruption of gene NCgl2106 results in a mutant devoid of monoacylated phosphatidyl-myo-inositol dimannoside (Ac1PIM2) resulting in the accumulation of monoacylated phosphatidyl-myo-inositol monomannoside Ac1PIM1 and cessation of phosphatidyl-myo-inositol based lipomannan and lipoarabinomannan biosynthesis. The mutant syntheses a single novel lipoglycan possessing an alpha-D-glucopyranosyluronic acid-(1->3)-glycerol (GlcAGroAc2) based anchor which is then further glycosylated by 822 mannose residues, with Man1220GlcAGroAC2 molecular species being the most abundant
physiological function
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both mannosyltransferases PimA and PimB' (MSMEG_4253) recognize phosphatidyl-myo-inositol as a lipid acceptor. PimA specifically catalyzes the transfer of a mannopyranosyl residue to the 2-position of the myo-inositol ring of phosphatidylinositol, whereas PimB' exclusively transfers to the 6-position. PimB' can catalyze the transfer of a mannopyranosyl residue onto the phosphatidylinositol-monomannoside (PIM1) product of PimA, while PimA is unable in vitro to transfer mannopyranosyl onto the PIM1 product of PimB'
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physiological function
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characterization of a PimB MgtA double deletion mutant. Gene product of Rv2188c acts as an Ac1PIM1:mannosyltransferase PimB and the product of Rv0557 acts as a GlcAGroAc2:mannosyltransferase MgtA
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physiological function
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disruption of gene NCgl2106 results in a mutant devoid of monoacylated phosphatidyl-myo-inositol dimannoside (Ac1PIM2) resulting in the accumulation of monoacylated phosphatidyl-myo-inositol monomannoside Ac1PIM1 and cessation of phosphatidyl-myo-inositol based lipomannan and lipoarabinomannan biosynthesis. The mutant syntheses a single novel lipoglycan possessing an alpha-D-glucopyranosyluronic acid-(1->3)-glycerol (GlcAGroAc2) based anchor which is then further glycosylated by 822 mannose residues, with Man1220GlcAGroAC2 molecular species being the most abundant
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