2.4.1.222: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.222

2.4.1.222

notch

glycosyltransferases

somite

mesoderm

n-glycans

presomitic

n-acetylglucosamine

somitogenesis

udp-n-acetylglucosamine

galactosyltransferase

delta1

jagged1

paraxial

dll1

delta-like

bisect

fucose-specific

unsegmented

o-fucosylation

n-acetyllactosamine

o-mannose

glcnac-ts

delta-notch

n-acetylglucosaminylated

pomgnt1s

poly-n-acetyllactosamine

o-fucosyltransferase

tetraantennary

gnt-ivs

o-mannosylated

synthesis

medicine

Reaction

PCQNGGS(O-D-GlcNAcbeta(1-3)-L-Fucbeta)-CKDQL

Synonyms

acetylglucosaminylferase, uridine diphosphoacetylglucosamine:fucosyglycoprotein beta1-3-, beta-1,3-N-acetyl-glucosaminyltransferase, beta-1,3-N-acetylglucosaminyltransferase, beta1,3-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase-2, beta1,3-N-acetylglusoaminyltransferase, Dfng, FNG, Fringe, fringe beta1,3 N-acetylglucosaminyltransferase, fringe glycosyltransferase, Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferase, Fringe protein, glycosyltransferase Fringe, LFNG, Lunatic Fringe, lunatic fringe glycosyltransferase, Maniac Fringe, Manic fringe, manic fringe glycosyltransferase, MFng, N-acetylglucosaminyltransferase, O-fucose-beta1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide-3-beta-N-acetylglucosaminyltransferase, Radical Fringe, radical fringe glycosyltransferase, Rfng, UDP-acetylglucosamine:fucosylglycoprotein, UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase, UDP-GlcNAc:fucose beta1,3 N-acetylglucosaminyltransferase, UDP-glucose:O-linked fucose beta1,3-glucosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.222 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

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Results	in table
5	Activating Compound
1545	AA Sequence
2	Application
1	CAS Registry Number
22	Cloned(Commentary)
3	Crystallization (Commentary)
226	Disease/ Diagnostics
1	Expression
38	General Information
5	Inhibitors
2	Ki Value [mM]
20	KM Value [mM]
13	Localization
6	Metals/Ions
5	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
48	Organism
1	Pathway
2	PDB ID
2	pH Optimum
1	Posttranslational Modification
42	Protein Variants
5	Purification (Commentary)
4	Reaction
9	Reaction Type
46	Reference
34	Source Tissue
3	Specific Activity [micromol/min/mg]
67	Substrates and Products (Substrate)
2	Subunits
88	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.4.1.222 - O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

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UDP-N-acetyl-alpha-D-glucosamine:[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)

The enzyme, found in animals and plants, is involved in the biosynthesis of the tetrasaccharides alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc and alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc, which are attached to L-Ser or L-Thr residues within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys in EGF-like domains in Notch and Factor-X proteins, respectively. The substrate is provided by EC 2.4.1.221, peptide-O-fucosyltransferase.