2.3.1.271: L-glutamate-5-semialdehyde N-acetyltransferase
This is an abbreviated version!
For detailed information about L-glutamate-5-semialdehyde N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.271
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2.3.1.271
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l-proline
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l-azetidine-2-carboxylic
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signalosome
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pombe
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detoxifies
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schizosaccharomyces
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sigma1278b
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four-membered
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misfolded
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znii2cys6
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fission
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photomorphogenesis
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binuclear
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triplets
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spacing
- 2.3.1.271
- l-proline
-
l-azetidine-2-carboxylic
-
signalosome
- pombe
-
detoxifies
-
schizosaccharomyces
- sigma1278b
-
four-membered
-
misfolded
-
znii2cys6
-
fission
-
photomorphogenesis
-
binuclear
-
triplets
-
spacing
Reaction
Synonyms
AZC acetyltransferase, AZC-detoxifying enzyme, L-azetidine-2-carboxylate N-acetyltransferase, MPR1, Mpr1p, MPR2, ppr1(+), Ppr1p
ECTree
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Systematic Name
Systematic Name on EC 2.3.1.271 - L-glutamate-5-semialdehyde N-acetyltransferase
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acetyl-CoA:L-glutamate-5-semialdehyde N-acetyltransferase
The enzyme, characterized from the yeast Saccharomyces cerevisiae Sigma1278b, N-acetylates L-glutamate-5-semialdehyde, an L-proline biosynthesis/utilization intermediate, into N-acetyl-L-glutamate 5-semialdehyde, an intermediate of L-arginine biosynthesis, under oxidative stress conditions. Its activity results in conversion of L-proline to L-arginine, and reduction in the concentration of L-glutamate 5-semialdehyde and its equilibrium partner, (S)-1-pyrroline-5-carboxylate, which has been linked to production of reactive oxygen species stress. The enzyme also acts on (S)-1-acetylazetidine-2-carboxylate, a toxic L-proline analog produced by some plants, resulting in its detoxification and conferring resistance on the yeast.