2.3.1.225: protein S-acyltransferase

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For detailed information about protein S-acyltransferase, go to the full flat file.

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Synonyms

Akr1, Akr1p, APT1, Asp-His-His-Cys motif palmitoyl transferase, At3g51390, DHHC palmitoyl transferase, DHHC protein, DHHC protein acyltransferase, DHHC-2, DHHC-21, DHHC-21 palmitoyl transferase, DHHC-3, DHHC-3 palmitoyl transferase, DHHC-7, DHHC-8, DHHC-CRD S-acyltransferase, DHHC16, DHHC17, DHHC2, DHHC3, DHHC4, DHHC5, Erf2, Erf2p, G-protein palmitoyltransferase, HIP14, palmitoyl acyltransferase, Pat, PAT10, PAT14, PAT15, PAT21, PAT24, PAT4, Pfa3, Pfa4, PFA5, protein acyl transferase, protein acyltransferase, protein S-acyl transferase 4, Ras PAT, S-protein acyltransferase, SEC18p, Swf1, ZDHHC3, ZDHHC5

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.225 protein S-acyltransferase

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Results	in table
4	Activating Compound
50827	AA Sequence
1	Application
11	Cloned(Commentary)
117	Disease/ Diagnostics
2	Expression
55	General Information
12	Inhibitors
7	KM Value [mM]
61	Localization
1	Metals/Ions
2	Molecular Weight [Da]
53	Natural Substrates/ Products (Substrates)
77	Organism
44	PDB ID
11	pH Optimum
2	Posttranslational Modification
17	Protein Variants
7	Purification (Commentary)
3	Reaction
43	Reference
41	Source Tissue
148	Substrates and Products (Substrate)
4	Subunits
147	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
3	Temperature Stability [°C]

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Application on EC 2.3.1.225 - protein S-acyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

Q9NYG2

DHHC3 is upregulated in malignant and metastatic human breast cancer. Elevated expression of DHHC3 correlates with diminished patient survival in breast cancer and six other human cancer types. DHHC3 ablation in human MDA-MB-231 mammary tumor cell xenografts reduces the sizes of both the primary tumor and metastatic lung colonies. Increased oxidative stress and senescence is observed in DHHC3-ablated cells. DHHC3-ablated tumors also show enhanced recruitment of innate immune cells associated with clearance of senescent tumors. Concomitant ablation of the upregulated oxidative stress protein TXNIP substantially negates the effects of DHHC3 depletion on oxidative stress and senescence

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