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2.3.1.21: carnitine O-palmitoyltransferase

This is an abbreviated version!
For detailed information about carnitine O-palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.21

Reaction

palmitoyl-CoA
+
L-carnitine
=
CoA
 +
L-palmitoylcarnitine

Synonyms

acylcarnitine transferase, carnitine O-palmitoyltransferase, carnitine O-palmitoyltransferase I, carnitine palmitoyl transferase 1, carnitine palmitoyl transferase 1A, carnitine palmitoyl transferase-1A, carnitine palmitoyl transferase-I, carnitine palmitoyl-transferase-1c, carnitine palmitoyltransferae 1A, carnitine palmitoyltransferase, carnitine palmitoyltransferase 1, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1B, carnitine palmitoyltransferase 2, carnitine palmitoyltransferase I, carnitine palmitoyltransferase IA, carnitine palmitoyltransferase II, carnitine palmitoyltransferase-1, carnitine palmitoyltransferase-1c, carnitine palmitoyltransferase-A, carnitine palmitoyltransferase-I, carnitine palmitoyltransferases 2, CPT, CPT I, CPT IA, CPT Ialpha1a, CPT Ialpha1b, CPT Ialpha2a, CPT Ibeta, CPT II, CPT-1, CPT-2, CPT-A, CPT-B, CPT-Ialpha, CPT-IL, CPT1, CPT1-A, CPT1-B, CPT1-C, CPT1A, CPT1B, CPT1c, CPT2, CPTi, CPTI beta, CPTII, CPTo, L-carnitine palmitoyltransferase, L-CPT 1, L-CPT1, M-CPT 1, M-CPTI, muscle carnitine palmitoyltransferase I, palmitoylcarnitine transferase, palmitoyltransferase, carnitine

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.21 carnitine O-palmitoyltransferase

Cloned

Cloned on EC 2.3.1.21 - carnitine O-palmitoyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
2 isoforms of CPT I, liver L-CPT I, skeletal muscle M-CPT I, cloned from liver, expression in Pichia pastoris GS115, DNA sequence determination
-
a rat promoter CPT-Ialpha luciferase vector is constructed
-
adenovirus-mediated (over)expression in cultured fed rat hepatocyte
-
clonig of CPT I and II from liver, expression in Pichia pastoris
-
cloning and expression of CPT II in Escherichia coli, overexpression of CPT II in Spodoptera frugiperda Sf 9 cells via baculavirus infection, DNA sequence analysis
-
cloning of liver mitochondrial CPT II from genetic library, in vitro transcription and translation, DNA sequence analysis, expression in COS cells
-
construction of 6 chimeric proteins with exchanges structure segments of L-CPT I and M-CPT I, expression of chimeric mutants and wild-type isoforms in Pichia pastoris
-
construction of chimeric L-CPT I with deletions and exchanged C-terminal sequences between rat and pig enzymes, expression in Pichia pastoris
COS-1 cells are transiently transfected to express a fusion protein in which enhanced green fluorescent protein is fused to the C-terminus of L-CPT1. This fusion protein is localized to mitochondria, and possibly to peroxisomes, but not to the endoplasmic reticulum
-
CPT1c cDNA is amplified and cloned into the pBlueScript vector, sequenced and subsequently cloned into pEGFP-N3, the coding regions of CPT1a and CPT1c are cloned into vector pIRES2-EGFP, chimeras between CPT1c and CPT1a are constructed
-
CPTI beta is expressed in Pichia pastoris
expressed in COS-7 cell
expressed in Escherichia coli and COS-7 cells
-
expressed in Pichia pastoris
expressed in the distal hindlimb muscles of Rattus norvegicus
expression in Escherichia coli
expression in Pichia pastoris
Q7YQR7, Q8SPI7
expression in rat brown adipocyte cell line
expression in Saccharomyces cerevisiae
expression of carnitine palmitoyltransferase I wild-type and mutant enzymes in Saccharomyces cerevisiae
expression of CPT I in Saccharomyces cerevisiae
-
expression of His-tagged L-CPT I in Pichia pastoris
-
expression of L-CPT I in Saccharomyces cerevisiae, recombinant and native enzyme show the same biochemical properties
-
expression of wild-type and mutant isozyme CPT1A in Saccharomyces cerevisiae
-
expression of wild-type and mutant isozymes M-CPT I in Pichia pastoris strain GS115
-
gene CPT 1B, overexpression in isolated extensor digitorum longus, EDL, muscle strips, electrotransfection
-
gene cpt1c, expression in HEK-293T cells
-
in vitro transcription and translation of L-CPT I
-
isozymes CPT1 and CPT2
-
mutant enzymes expressed in Pichia pastoris
overexpression of isozymes M-CPT I and L-CPT I in Saccharomyces cerevisiae
-
overexpression of M-CPT I in Pichia pastoris, containing about 24 copies of the expression vector
-
quantitative expression analysis
-
quantitative expression analysis, expression in Huh-7 cells, treatment with clofibrate induces the enzyme expression
-
recombinant adenoviruses containing cDNAs encoding rat CPT1a and rat CPT2 are constructed