2.3.1.208: 4-hydroxycoumarin synthase
This is an abbreviated version!
For detailed information about 4-hydroxycoumarin synthase, go to the full flat file.
Reaction
Synonyms
biphenyl synthase, BIS, BIS1, BIS2, BIS3, More
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.3.1.208 - 4-hydroxycoumarin synthase
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REACTION DIAGRAM
malonyl-CoA + 3-hydroxybenzoyl-CoA
2 CoA + 2-oxabicyclo[4.3.1]deca-1(10),6,8-triene-3,5-dione + CO2
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malonyl-CoA + 2-hydroxybenzoyl-CoA
2 CoA + 4-hydroxycoumarin + CO2
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malonyl-CoA + 2-hydroxybenzoyl-CoA
2 CoA + 4-hydroxycoumarin + CO2
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malonyl-CoA + 2-hydroxybenzoyl-CoA
2 CoA + 4-hydroxycoumarin + CO2
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for the bifunctional BIS, the preferred starter substrates are benzoyl-CoA and salicoyl-CoA, leading to the formation of 3,5-dihydroxybiphenyl and 4-hydroxycoumarin, EC 2.3.1.177 and 2.3.1.208, respectively, in the presence of malonyl-CoA as extender molecule
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additional information
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bifunctional enzyme, biphenyl synthase, BIS, catalyzes the formation of a linear tetraketide intermediate from benzoyl-CoA and three molecules of malonyl-CoA but uses an alternative intramolecular cyclization reaction to form 3,5-dihydroxybiphenyl, EC 2.3.1.177. When incubated with 2-hydroxybenzoyl (salicyl)-CoA, BIS catalyzes a single decarboxylative condensation with malonyl-CoA to form 4-hydroxycoumarin, EC 2.3.1.208
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additional information
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biphenyl synthase isozyme BIS1, in contrast to isozymes BIS2 and BIS3, does not prefer 2-hydroxybenzoyl (salicyl)-CoA as a starter substrat, but also catalyzes a single decarboxylative condensation with malonyl-CoA to give 4-hydroxycoumarin
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additional information
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biphenyl synthase isozyme BIS1, in contrast to isozymes BIS2 and BIS3, does not prefer 2-hydroxybenzoyl (salicyl)-CoA as a starter substrat, but also catalyzes a single decarboxylative condensation with malonyl-CoA to give 4-hydroxycoumarin
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additional information
?
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biphenyl synthase isozyme BIS1, in contrast to isozymes BIS2 and BIS3, does not prefer 2-hydroxybenzoyl (salicyl)-CoA as a starter substrat, but also catalyzes a single decarboxylative condensation with malonyl-CoA to give 4-hydroxycoumarin
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?
additional information
?
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for the bifunctional BIS, the preferred starter substrates are benzoyl-CoA and salicoyl-CoA, leading to the formation of 3,5-dihydroxybiphenyl and 4-hydroxycoumarin, EC 2.3.1.177 and 2.3.1.208, respectively, in the presence of malonyl-CoA as extender molecule
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additional information
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in contrast to isozyme BIS1, biphenyl synthase isoenzymes BIS2 and BIS3 prefer ortho-hydroxybenzoyl (salicyl)-CoA as a starter substrate and catalyze a single decarboxylative condensation with malonyl-CoA to give 4-hydroxycoumarin
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additional information
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in contrast to isozyme BIS1, biphenyl synthase isoenzymes BIS2 and BIS3 prefer ortho-hydroxybenzoyl (salicyl)-CoA as a starter substrate and catalyze a single decarboxylative condensation with malonyl-CoA to give 4-hydroxycoumarin
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?
additional information
?
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in contrast to isozyme BIS1, biphenyl synthase isoenzymes BIS2 and BIS3 prefer ortho-hydroxybenzoyl (salicyl)-CoA as a starter substrate and catalyze a single decarboxylative condensation with malonyl-CoA to give 4-hydroxycoumarin
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