2.1.1.B130: [histone H3]-N-methyllysine9 N-methyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-N-methyllysine9 N-methyltransferase, go to the full flat file.

Reaction

Synonyms

SU(VAR)3-9 RELATED4, SUVR4

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.B130 [histone H3]-N-methyllysine9 N-methyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
1	AA Sequence
1	Crystallization (Commentary)
2	General Information
1	Inhibitors
1	Localization
3	Organism
4	Protein Variants
4	Reaction
3	Reference
8	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name

Substrates Products

print visible entries

print all entries

Substrates Products on EC 2.1.1.B130 - [histone H3]-N-methyllysine9 N-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine

N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine

Arabidopsis thaliana

Q8W595

-

760011

-

-

?

N6-methyl-L-lysyl9-[histone H3 peptide 1-20] + S-adenosyl-L-methionine

N6,N6-dimethyl-L-lysyl9-[histone H3 peptide 1-20] + S-adenosyl-L-homocysteine

Arabidopsis thaliana

Q8W595

-

759859

-

-

?

N6-methyl-L-lysyl9-[histone H3 peptide 5-11] + S-adenosyl-L-methionine

N6,N6-dimethyl-L-lysyl9-[histone H3 peptide 5-11] + S-adenosyl-L-homocysteine

Arabidopsis thaliana

Q8W595

-

759859

-

-

?

N6-methyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine

N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine

Arabidopsis thaliana

Q8W595

-

760011

-

-

?

N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine

N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine

Arabidopsis thaliana

Q8W595

-

759859, 760011

-

-

?

additional information

?

-

2 entries

additional information

?

-

Arabidopsis thaliana

Q8W595

in the absence of ubiquitin, SUVR4 converts 40.9% of the H3K9me1 peptide to H3K9me2, while 0% is converted to H3K9me3. In the presence of ubiquitin, 90.2% of the H3K9me1 peptide is converted to H3K9me2 while 3.5% is converted to H3K9me3. When H3K9me2 peptides are used as substrate, there is no conversion to H3K9me3 above background level in the absence of ubiquitin. When ubiquitin is present together with SUVR4, a 16.4% conversion from H3K9me2 to H3K9me3 is found

760011

-

-

-

additional information

?

-

Arabidopsis thaliana

Q8W595

SUVR4 protein shows very low histone methyltransferase activity against the unmethylated histone H3 1-20 peptide. SUVR4 is also unable to methylate H3 1-20 peptides monomethylated at K4 or dimethylated at K9. SUVR4 is able to methylate histone H3 peptides of variable size when monomethylated at K9, but not when monomethylated at K4 or K27 or dimethylated on K9

759859

-

-

-