2.1.1.B124: 16S rRNA (guanine1370-2'-O)-methyltransferase
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For detailed information about 16S rRNA (guanine1370-2'-O)-methyltransferase, go to the full flat file.
Reaction
Synonyms
MRM3, RMTL1, RNMTL1
ECTree
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General Information
General Information on EC 2.1.1.B124 - 16S rRNA (guanine1370-2'-O)-methyltransferase
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physiological function
MRM2 and MRM3 are responsible for modification of nucleotides of the 16S rRNA A-loop, an essential component of the peptidyl transxadferase center. Inactivation of MRM2 or MRM3 in human cells by RNA interference results in respiratory incompetence as a consequence of diminished mitochondrial translation. Ineffective translation in MRM2- and MRM3-depleted cells results from aberxadrant assembly of the large subunit of the mitochondrial ribosome
physiological function
knockdown of MRM3 significantly increases accessibility of 16 S rRNA to DNAzyme cleavage at residue G1370