2.1.1.356: [histone H3]-lysine27 N-trimethyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-lysine27 N-trimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.356
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2.1.1.356
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chromatin
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trimethylation
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zeste
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tumorigenesis
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pluripotency
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repressor
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lncrnas
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prc2-mediated
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leukemia
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heterochromatin
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epigenome
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ectoderm
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methyltransferases
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self-renewal
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jarid2
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bivalent
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prc1
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h3k4me3
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nucleosome
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imprint
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cdkn2a
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demethylase
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dznep
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vernalization
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h3k27ac
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ezh2-mediated
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hotair
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de-repression
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3-deazaneplanocin
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lysine-27
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ctcf
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jumonji
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mescs
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analysis
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polycomb-group
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curly
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trithorax
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homeotic
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synthesis
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mpnsts
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polycomb-mediated
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chromatin-modifying
- 2.1.1.356
- chromatin
-
trimethylation
-
zeste
- tumorigenesis
-
pluripotency
- repressor
- lncrnas
-
prc2-mediated
- leukemia
-
heterochromatin
-
epigenome
- ectoderm
- methyltransferases
-
self-renewal
- jarid2
-
bivalent
- prc1
-
h3k4me3
- nucleosome
-
imprint
-
cdkn2a
- demethylase
-
dznep
-
vernalization
-
h3k27ac
-
ezh2-mediated
-
hotair
-
de-repression
-
3-deazaneplanocin
-
lysine-27
- ctcf
-
jumonji
-
mescs
- analysis
-
polycomb-group
-
curly
-
trithorax
-
homeotic
- synthesis
- mpnsts
-
polycomb-mediated
-
chromatin-modifying
Reaction
3 S-adenosyl-L-methionine + = 3 S-adenosyl-L-homocysteine +
Synonyms
CLF, EC 2.1.1.43, EZH1, EZH2, G9a, histone H3 K27 methyltransferase, histone H3 lysine 27 methyltransferase, histone lysine methyltransferase, HMTase, interleukin-5 response element II binding protein, KMT6, KMT6A, KMT6B, lysine-preferring HMTase, NSD2, NSD3, Polycomb repressive complex 2, PRC2, RE-IIBP, SET, SET domain histone lysine methyltransferase, SETDB1, TXR1, vSET, WHSC1/MMSET isoform RE-IIBP
ECTree
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Reaction
Reaction on EC 2.1.1.356 - [histone H3]-lysine27 N-trimethyltransferase
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3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
overall reaction
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S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
(1a)
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S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
(1c)
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