2.1.1.204: tRNA (cytosine38-C5)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (cytosine38-C5)-methyltransferase, go to the full flat file.

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Synonyms

(cytosine-5) RNA methyltransferase, cytosine-5 tRNA methyltransferase, dDnmt2, DNA methyltransferase 2, DnmA, Dnmt2, DNMT2 methyltransferase, EC 2.1.1.29, hDNMT2, Pf-DNMT2, PMT1, pombe methyltransferase 1, RCMT, RNA methyltransferase, spDnmt2, transfer RNA aspartic acid methyltransferase 1, TRDMT1, tRNA aspartic acid methyltransferase 1, tRNA-aspartic acid methyltransferase 1

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.204 tRNA (cytosine38-C5)-methyltransferase

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Results	in table
5	Activating Compound
249	AA Sequence
9	Cloned(Commentary)
20	Cofactor
1	Crystallization (Commentary)
126	Disease/ Diagnostics
3	Expression
61	General Information
2	Inhibitors
5	KM Value [mM]
9	Localization
6	Metals/Ions
56	Natural Substrates/ Products (Substrates)
40	Organism
4	PDB ID
7	pH Optimum
51	Protein Variants
5	Purification (Commentary)
2	Reaction
34	Reference
43	Source Tissue
82	Substrates and Products (Substrate)
1	Subunits
58	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.204 - tRNA (cytosine38-C5)-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + cytosine38 in G34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in G34tRNAAsp

3 entries

S-adenosyl-L-methionine + cytosine38 in Q34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in Q34tRNAAsp

3 entries

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

9 entries

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

12 entries

S-adenosyl-L-methionine + cytosine38 in tRNAAsp precursor

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp precursor

Homo sapiens

-

-

736856

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp(GTC)

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp(GTC)

Arabidopsis thaliana

-

-

735864

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAspGTC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAspGTC

2 entries

S-adenosyl-L-methionine + cytosine38 in tRNAGly precursor

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGly precursor

Homo sapiens

-

-

736856

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAGly(GCC)

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGly(GCC)

Arabidopsis thaliana

-

-

735864

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAGlyGCC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGlyGCC

2 entries

S-adenosyl-L-methionine + cytosine38 in tRNAVal precursor

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAVal precursor

Homo sapiens

-

-

736856

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAValAAC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAValAAC

2 entries

additional information

?

-

14 entries

S-adenosyl-L-methionine + cytosine38 in G34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in G34tRNAAsp

Schizosaccharomyces pombe

P40999

-

758443

-

-

?

S-adenosyl-L-methionine + cytosine38 in G34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in G34tRNAAsp

Schizosaccharomyces pombe 972

P40999

-

758443

-

-

?

S-adenosyl-L-methionine + cytosine38 in G34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in G34tRNAAsp

Schizosaccharomyces pombe ATCC 24843

P40999

-

758443

-

-

?

S-adenosyl-L-methionine + cytosine38 in Q34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in Q34tRNAAsp

Schizosaccharomyces pombe

P40999

preferred substrate

758443

-

-

?

S-adenosyl-L-methionine + cytosine38 in Q34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in Q34tRNAAsp

Schizosaccharomyces pombe 972

P40999

preferred substrate

758443

-

-

?

S-adenosyl-L-methionine + cytosine38 in Q34tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in Q34tRNAAsp

Schizosaccharomyces pombe ATCC 24843

P40999

preferred substrate

758443

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Dictyostelium discoideum

-

-

736905

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Drosophila melanogaster

Q9U6H7

-

756399

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Drosophila melanogaster

Q9VKB3

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Drosophila melanogaster

Q9U6H7

RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage

708588

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Homo sapiens

O14717

-

710560

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Mus musculus

O55055

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Schizosaccharomyces pombe

P40999

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Schizosaccharomyces pombe 972

P40999

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNA

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA

Schizosaccharomyces pombe ATCC 24843

P40999

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Bos taurus

-

-

735727

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Drosophila melanogaster

Q9VKB3

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Homo sapiens

-

-

718931, 735726, 735727

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Homo sapiens

O14717

-

756387, 758319

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Mus musculus

O55055

-

735727, 756159, 756387

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Mus musculus

-

-

756387

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Mus musculus

O55055

-

758319

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Plasmodium falciparum

Q8IBI4

-

756078

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Schizosaccharomyces pombe

-

-

736905

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Schizosaccharomyces pombe

P40999

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Schizosaccharomyces pombe 972

P40999

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAsp

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp

Schizosaccharomyces pombe ATCC 24843

P40999

-

756159

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAspGTC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAspGTC

Mus musculus

O55055

Dnmt2-mediated methylation at position C38 in the anticodon loop of tRNA-Asp may have a role in the discrimination between Asp and Glu near-cognate codons

736018

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAAspGTC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAspGTC

Mus musculus C57BL/6

O55055

Dnmt2-mediated methylation at position C38 in the anticodon loop of tRNA-Asp may have a role in the discrimination between Asp and Glu near-cognate codons

736018

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAGlyGCC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGlyGCC

Mus musculus

O55055

-

736018

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAGlyGCC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGlyGCC

Mus musculus C57BL/6

O55055

-

736018

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAValAAC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAValAAC

Mus musculus

O55055

-

736018

-

-

?

S-adenosyl-L-methionine + cytosine38 in tRNAValAAC

S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAValAAC

Mus musculus C57BL/6

O55055

-

736018

-

-

?

additional information

?

-

Bos taurus

-

the enzyme DNMT2 is responsible for methylation of cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl group to the cytosine residues of DNA

735727

-

-

?

additional information

?

-

Dictyostelium discoideum

-

Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs

736905

-

-

?

additional information

?

-

Drosophila melanogaster

Q9VKB3

Dnmt2 enzymes are transfer RNA (tRNA) methyltransferases for cytosine-5 methylation, foremost C38 (m5C38) of tRNAAsp. Dnmt2 binds to viral RNA

756159

-

-

-

additional information

?

-

Homo sapiens

-

DNMT2 functions primarily, if not exclusively, as a cytosine 5-methylation RNA methyltransferase with three verified tRNA targets: tRNAAsp, tRNAGly and tRNAVal

736856

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme DNMT2 is responsible for methylation of cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl group to the cytosine residues of DNA

735727

-

-

?

additional information

?

-

Mus musculus

O55055

Dnmt2 methylates C38 of tRNA in the bone marrow and modulates the stability and fragmentation of substrate tRNAs

736018

-

-

?

additional information

?

-

Mus musculus

O55055

the enzyme DNMT2 is responsible for methylation of cytosine 38 in the anticodon loop of aspartic acid transfer RNA instead of transferring methyl group to the cytosine residues of DNA

735727

-

-

?

additional information

?

-

Mus musculus

O55055

Dnmt2 enzymes are transfer RNA (tRNA) methyltransferases for cytosine-5 methylation, foremost C38 (m5C38) of tRNAAsp. Dnmt2 binds to viral RNA

756159

-

-

-

additional information

?

-

Mus musculus C57BL/6

O55055

Dnmt2 methylates C38 of tRNA in the bone marrow and modulates the stability and fragmentation of substrate tRNAs

736018

-

-

?

additional information

?

-

Plasmodium falciparum

Q8IBI4

the DNA methyltransferase homologue TRDMT1 in Plasmodium falciparum specifically methylates endogenous aspartic acid tRNA

756078

-

-

-

additional information

?

-

Schizosaccharomyces pombe

-

Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. Pmt1 shows a striking selectivity for tRNAAsp methylation, which distinguishes Pmt1 from other Dnmt2 homologues. C34 of tRNAPro is a Pmt1- and queuosine-independent tRNA methylation site in Schizosaccharomyces pombe

736905

-

-

?

additional information

?

-

Schizosaccharomyces pombe

P40999

Dnmt2 enzymes are transfer RNA (tRNA) methyltransferases for cytosine-5 methylation, foremost C38 (m5C38) of tRNAAsp

756159

-

-

-

additional information

?

-

Schizosaccharomyces pombe 972

P40999

Dnmt2 enzymes are transfer RNA (tRNA) methyltransferases for cytosine-5 methylation, foremost C38 (m5C38) of tRNAAsp

756159

-

-

-

additional information

?

-

Schizosaccharomyces pombe ATCC 24843

P40999

Dnmt2 enzymes are transfer RNA (tRNA) methyltransferases for cytosine-5 methylation, foremost C38 (m5C38) of tRNAAsp

756159

-

-

-