1.8.5.9: protein dithiol:quinone oxidoreductase DsbB

This is an abbreviated version!
For detailed information about protein dithiol:quinone oxidoreductase DsbB, go to the full flat file.

Reaction

Synonyms

C. trachomatis disulfide bond protein B, CtDsbB, disulfide bond formation protein B, disulfide bond oxidoreductase B, disulfide bond protein B, disulfide-bond formation protein B, DsbB, membrane protein disulfide bond protein B, Rv2968c, thiol:disulfide oxidoreductase, VKOR homolog

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.5 With a quinone or similar compound as acceptor

                1.8.5.9 protein dithiol:quinone oxidoreductase DsbB

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Results	in table
2	Activating Compound
3	AA Sequence
7	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
8	General Information
1	IC50 Value
1	Inhibitors
1	KM Value [mM]
28	Localization
47	Natural Substrates/ Products (Substrates)
220	Organism
23	Protein Variants
6	Purification (Commentary)
3	Reaction
29	Reference
60	Substrates and Products (Substrate)
5	Subunits
44	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.8.5.9 - protein dithiol:quinone oxidoreductase DsbB

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

a [DsbA protein] with reduced L-cysteine residues + a quinone

a [DsbA protein] carrying a disulfide bond + a quinol

Escherichia coli

-

overall reaction

755674, 756585, 757136

-

-

?

a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond

a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues

Escherichia coli

-

-

756115, 756585

-

-

?

a [DsbA protein] with reduced L-cysteine residues + menaquinone

a [DsbA protein] carrying a disulfide bond + menaquinol

Escherichia coli

-

under unaerobic conditions, overall reaction

757693

-

-

?

a [DsbA protein] with reduced L-cysteine residues + ubiquinone

a [DsbA protein] carrying a disulfide bond + ubiquinol

2 entries

a [DsbB protein] with reduced L-cysteine residues + a quinone

a [DsbB protein] carrying a disulfide bond + a quinol

Escherichia coli

-

-

756585

-

-

?

a [DsbB protein] with reduced L-cysteine residues + ubiquinone

a [DsbB protein] carrying a disulfide bond + ubiquinol

Escherichia coli

-

-

756115

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

7 entries

[DsbA protein] with reduced L-cysteine residues + menaquinone

[DsbA protein] carrying a disulfide bond + menaquinol

Escherichia coli

-

overall reaction

757516, 758211

-

-

?

[DsbA protein] with reduced L-cysteine residues + quinone

[DsbA protein] carrying a disulfide bond + quinol

2 entries

[DsbA protein] with reduced L-cysteine residues + ubiquinone

[DsbA protein] carrying a disulfide bond + ubiquinol

2 entries

[DsbA protein] with reduced L-cysteine residues + ubiquinone Q8

[DsbA protein] carrying a disulfide bond + ubiquinol Q8

Escherichia coli

P0A6M2

overall reaction

756717

-

-

?

[DsbA protein] with reduced L-cysteine residues + ubiquinone-1

[DsbA protein] carrying a disulfide bond + ubiquinol-1

2 entries

[DsbA protein] with reduced L-cysteine residues + [DsbB protein] carrying a disulfide bond

[DsbA protein] carrying a disulfide bond + [DsbB protein] with reduced L-cysteine residues

4 entries

[DsbB protein] with reduced L-cysteine residues + a quinone

[DsbB protein] carrying a disulfide bond + a quinol

Escherichia coli

-

-

757124

-

-

?

[DsbB protein] with reduced L-cysteine residues + ubiquinone

[DsbB protein] carrying a disulfide bond + ubiquinol

2 entries

[DsbB protein] with reduced L-cysteine residues + ubiquinone-1

[DsbB protein] carrying a disulfide bond + ubiquinol-1

2 entries

additional information

?

-

2 entries

a [DsbA protein] with reduced L-cysteine residues + ubiquinone

a [DsbA protein] carrying a disulfide bond + ubiquinol

Escherichia coli

-

overall reaction

755706, 756115

-

-

?

a [DsbA protein] with reduced L-cysteine residues + ubiquinone

a [DsbA protein] carrying a disulfide bond + ubiquinol

Escherichia coli

-

under aerobic conditions, overall reaction

757693

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

Bacteroides fragilis

-

overall reaction

758212

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

Bacteroides fragilis NCTC9343

-

overall reaction

758212

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

Burkholderia cepacia

-

overall reaction

757614

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

Burkholderia cepacia KF1

-

overall reaction

757614

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

Escherichia coli

-

overall reaction

756716, 756872, 757124, 758212, 758255, 758257

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

Mycobacterium tuberculosis

-

overall reaction

758212

-

-

?

[DsbA protein] with reduced L-cysteine residues + a quinone

[DsbA protein] carrying a disulfide bond + a quinol

Mycobacterium tuberculosis H37Rv

-

overall reaction

758212

-

-

?

[DsbA protein] with reduced L-cysteine residues + quinone

[DsbA protein] carrying a disulfide bond + quinol

Chlamydia trachomatis

G4NNC5

overall reaction

758183

-

-

?

[DsbA protein] with reduced L-cysteine residues + quinone

[DsbA protein] carrying a disulfide bond + quinol

Chlamydia trachomatis A2497

G4NNC5

overall reaction

758183

-

-

?

[DsbA protein] with reduced L-cysteine residues + ubiquinone

[DsbA protein] carrying a disulfide bond + ubiquinol

Escherichia coli

-

overall reaction

757146, 757516, 758211, 758288

-

-

?

[DsbA protein] with reduced L-cysteine residues + ubiquinone

[DsbA protein] carrying a disulfide bond + ubiquinol

Escherichia coli

P0A6M2

overall reaction

756589

-

-

?

[DsbA protein] with reduced L-cysteine residues + ubiquinone-1

[DsbA protein] carrying a disulfide bond + ubiquinol-1

Burkholderia pseudomallei

Q63RY4

overall reaction

756909

-

-

?

[DsbA protein] with reduced L-cysteine residues + ubiquinone-1

[DsbA protein] carrying a disulfide bond + ubiquinol-1

Burkholderia pseudomallei K96243

Q63RY4

overall reaction

756909

-

-

?

[DsbA protein] with reduced L-cysteine residues + [DsbB protein] carrying a disulfide bond

[DsbA protein] carrying a disulfide bond + [DsbB protein] with reduced L-cysteine residues

Burkholderia pseudomallei

Q63RY4

-

756909

-

-

?

[DsbA protein] with reduced L-cysteine residues + [DsbB protein] carrying a disulfide bond

[DsbA protein] carrying a disulfide bond + [DsbB protein] with reduced L-cysteine residues

Burkholderia pseudomallei K96243

Q63RY4

-

756909

-

-

?

[DsbA protein] with reduced L-cysteine residues + [DsbB protein] carrying a disulfide bond

[DsbA protein] carrying a disulfide bond + [DsbB protein] with reduced L-cysteine residues

Escherichia coli

-

-

757124, 757146

-

-

?

[DsbA protein] with reduced L-cysteine residues + [DsbB protein] carrying a disulfide bond

[DsbA protein] carrying a disulfide bond + [DsbB protein] with reduced L-cysteine residues

Escherichia coli

P0A6M2

-

756589

-

-

?

[DsbB protein] with reduced L-cysteine residues + ubiquinone

[DsbB protein] carrying a disulfide bond + ubiquinol

Escherichia coli

-

-

757146

-

-

?

[DsbB protein] with reduced L-cysteine residues + ubiquinone

[DsbB protein] carrying a disulfide bond + ubiquinol

Escherichia coli

P0A6M2

-

756589

-

-

?

[DsbB protein] with reduced L-cysteine residues + ubiquinone-1

[DsbB protein] carrying a disulfide bond + ubiquinol-1

Burkholderia pseudomallei

Q63RY4

-

756909

-

-

?

[DsbB protein] with reduced L-cysteine residues + ubiquinone-1

[DsbB protein] carrying a disulfide bond + ubiquinol-1

Burkholderia pseudomallei K96243

Q63RY4

-

756909

-

-

?

additional information

?

-

Escherichia coli

-

reduced DsbA forms a complex with the enzyme in which Cys30 of DsbA is disulfide-bonded to Cys104 of the enzyme. Cys104 is rapidly replaced by Cys33 of DsbA to generate the oxidized form of this protein

758255

-

-

-

additional information

?

-

Escherichia coli

-

the enzyme is initially oxidized (state A). Disulfide interaction between Cys30 of DsbA protein and Cys104 of the enzyme then triggers the recycling reaction of DsbA (state B), allowing over all electron transfer from newly secreted protein via DsbA (Cys30/Cys33) to the enzyme in which intra-chain electron flow from Cys104/Cys130 (state C) to Cys41/Cys44 (state D) may occur

756872

-

-

-