1.14.20.14: hapalindole-type alkaloid chlorinase

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For detailed information about hapalindole-type alkaloid chlorinase, go to the full flat file.

Word Map on EC 1.14.20.14

1.14.20.14

halogenase

chlorination

unactivated

late-stage

non-heme

welwitindolinone

biocatalyst

structure-guided

2-oxo-glutarate

medicine

Reaction

Synonyms

ambO5, AmbO5 protein, welO5, WelO5 protein, WelO5*

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

1.14.20.14 hapalindole-type alkaloid chlorinase

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Results	in table
1	Activating Compound
3	AA Sequence
2	Application
6	Cloned(Commentary)
1	Crystallization (Commentary)
3	General Information
4	Inhibitors
3	Metals/Ions
4	Natural Substrates/ Products (Substrates)
47	Organism
1	Pathway
3	pH Optimum
10	Protein Variants
7	Purification (Commentary)
2	Reaction
16	Reference
47	Substrates and Products (Substrate)
15	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
9	Turnover Number [1/s]

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Reference on EC 1.14.20.14 - hapalindole-type alkaloid chlorinase

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746748

Hillwig, M.L.; Zhu, Q.; Ittiamornkul, K.; Liu, X.

Discovery of a promiscuous non-heme iron halogenase in ambiguine alkaloid biogenesis implication for an evolvable enzyme family for late-stage halogenation of aliphatic carbons in small molecules

Angew. Chem. Int. Ed. Engl.

5780-5784

2016

Fischerella ambigua (A0A076NA91), Hapalosiphon welwitschii (A0A067YX61), Hapalosiphon welwitschii UTEX B 1830 (A0A067YX61)

27027281

746946

Zhu, Q.; Liu, X.

Characterization of non-heme iron aliphatic halogenase WelO5* from Hapalosiphon welwitschii IC-52-3 Identification of a minimal protein sequence motif that confers enzymatic chlorination specificity in the biosynthesis

Beilstein J. Org. Chem.

1168-1173

2017

Hapalosiphon welwitschii, Hapalosiphon welwitschii (A0A067YX61), Hapalosiphon welwitschii UTEX B 1830 (A0A067YX61), Hapalosiphon welwitschii IC-52-3

28684995

747541

Zhu, Q.; Hillwig, M.L.; Doi, Y.; Liu, X.

Aliphatic halogenase enables late-stage C-H functionalization selective synthesis of a brominated Fischerindole alkaloid with enhanced antibacterial activity

ChemBioChem

466-470

2016

Hapalosiphon welwitschii (A0A067YX61), Hapalosiphon welwitschii UTEX B 1830 (A0A067YX61)

26749394

748567

Liu, X.

In vitro analysis of cyanobacterial nonheme iron-dependent aliphatic halogenases WelO5 and AmbO5

Methods Enzymol.

604

389-404

2018

Hapalosiphon welwitschii (A0A067YX61), Fischerella ambigua (A0A1L1YPD7), Fischerella ambigua UTEX 1903 (A0A1L1YPD7), Hapalosiphon welwitschii UTEX B 1830 (A0A067YX61)

29779660

748728

Hillwig, M.L.; Liu, X.

A new family of iron-dependent halogenases acts on freestanding substrates

Nat. Chem. Biol.

921-923

2014

Hapalosiphon welwitschii (A0A067YX61), Hapalosiphon welwitschii UTEX B 1830 (A0A067YX61)

25218740

748732

Mitchell, A.J.; Zhu, Q.; Maggiolo, A.O.; Ananth, N.R.; Hillwig, M.L.; Liu, X.; Boal, A.K.

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

Nat. Chem. Biol.

636-640

2016

Hapalosiphon welwitschii (A0A067YX61), Hapalosiphon welwitschii UTEX B 1830 (A0A067YX61)

27348090