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1.14.15.25: p-cymene methyl-monooxygenase

This is an abbreviated version!
For detailed information about p-cymene methyl-monooxygenase, go to the full flat file.

Reaction

p-cymene
+
O2
 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ =
4-Isopropylbenzyl alcohol
 + 2 oxidized ferredoxin [iron-sulfur] cluster +
H2O

Synonyms

cymA, cymAa, CymB, CymM, p-cymene methyl hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.25 p-cymene methyl-monooxygenase

Substrates Products

Substrates Products on EC 1.14.15.25 - p-cymene methyl-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-(methylthio)toluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
4-(methylthio)benzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
O33456; O33457
-
-
-
?
4-chlorostyrene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
4-chlorostyrene oxide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
O33456; O33457
-
-
-
?
4-ethyltoluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
4-ethylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
O33456; O33457
-
-
-
?
4-fluorotoluene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
4-fluorobenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
O33456; O33457
-
-
-
?
p-cymene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
4-isopropylbenzyl alcohol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
O33456; O33457
-
-
-
?
styrene + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
styrene oxide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
O33456; O33457
-
-
-
?
additional information
?
-
O33456; O33457
enzyme can attack benzylic and toluic alcohols as well as toluene and xylenes, probably with the formation of gem-diol intermediates which spontaneously dehydrate to yield the corresponding aldehydes
-
-
?