1.14.14.B11: nicotine demethylase
This is an abbreviated version!
For detailed information about nicotine demethylase, go to the full flat file.
Word Map on EC 1.14.14.B11
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1.14.14.B11
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nornicotine
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nicotiana
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tabacum
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n-demethylation
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n'-nitrosonornicotine
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tobacco-specific
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nitrosamine
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burley
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demethylases
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tomentosiformis
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curing
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sylvestris
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s-nicotine
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nonconverter
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nutrition
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rnai-induced
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elicitor-induced
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agriculture
- 1.14.14.B11
- nornicotine
- nicotiana
- tabacum
-
n-demethylation
- n'-nitrosonornicotine
-
tobacco-specific
-
nitrosamine
-
burley
- demethylases
- tomentosiformis
-
curing
- sylvestris
-
s-nicotine
-
nonconverter
- nutrition
-
rnai-induced
-
elicitor-induced
- agriculture
Reaction
Synonyms
CYP82E, CYP82E1, CYP82E10, CYP82E2, CYP82E21, CYP82E3, CYP82E4, CYP82E4v1, CYP82E5v2, nicotine N-demethylase, NND
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General Information
General Information on EC 1.14.14.B11 - nicotine demethylase
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evolution
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N-demethylase enzymes (NND) belongs to the family of cytochrome P450 monooxygenases (CYP). The CYP82E21 gene is found in all Nicotiana tabacum cultivars analysed and originates from the tobacco ancestor Nicotiana tomentosiformis
malfunction
physiological function
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nornicotine formation can be reduced in ovaries by introducing a CYP82E21-specific RNAi construct
malfunction
Q38Q86
RNA interference of the nicotine demethylase gene CYP82E4v1 reduces nornicotine content and enhances Myzus persicae resistance in Nicotiana tabacum infected with aphids
only microsomes from yeast expressing the D121-AA8 cDNA exhibit significant nicotine demethylase activity
physiological function
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the CYP82E21 gene encodes a functional ovary-specific nicotine N-demethylase, nornicotine is formed by oxidative demethylation of nicotine