1.14.13.43: questin monooxygenase
This is an abbreviated version!
For detailed information about questin monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.43
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1.14.13.43
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prostaglandin
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prostaglandin-endoperoxide
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smoking
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aspirin
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nsaid
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docosahexaenoic
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asthma
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nonsteroidal
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omega-3
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adenoma
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neoplasia
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alox12
- 1.14.13.43
- prostaglandin
-
prostaglandin-endoperoxide
-
smoking
- aspirin
-
nsaid
-
docosahexaenoic
-
asthma
-
nonsteroidal
-
omega-3
-
adenoma
-
neoplasia
- alox12
Reaction
Synonyms
questin oxygenase
ECTree
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General Information
General Information on EC 1.14.13.43 - questin monooxygenase
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metabolism
Aspergillus sp. FVL2
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the organism is cultured on rice medium, and the secondary metabolites are analysed by chromatographic separation delivering three newly identified natural products, 7-demethyl-neosulochrin, fumigaclavine, and N-benzoyl-tryptophan together with further 14 metabolites, 1-O-methyl-sulochrin-4'-sulfate, questin, laccaic acid, isorhodoptilometrin, fumigaclavine A, fumigaclavine C, fumitremorgin C, fumigaquinazoline C, tryptoquivaline J, trypacidin, 3'-O-demethyl-sulochrin, 1-O-methyl-sulochrin, protocatechuic acid, and vermelone. The chemical structures of the three newly identified metabolites are determined by NMR spectroscopy and ESI HR mass spectrometry. The discovery of the seco-anthraquinone 7-demethyl-neosulochrin reveals a second type of ring cleavage by a questin oxygenase. Except for the moderate activity of trypacidin against Staphylococcus aureus, 7-demethyl-neosulochrin, 1-O-methyl-sulochrin, 1-O-methyl-sulochrin-4'-sulfate, isorhodoptilometrin, fumigaclavine A, fumigaclavine C, fumigaquinazoline C, tryptoquivaline J, 3'-O-demethyl-sulochrin and vermelone are inactive in the agar diffusion assay against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans. Demethylneosulochrin, 1-O-methyl-sulochrin-4'-sulfate, 1-O-methyl-sulochrin, fumigaclavine I, and 3-O-demethyl-sulochrin are tested additionally against the human leukemia HL-60 cell line but display no cytotoxicity