1.14.13.225: F-actin monooxygenase
This is an abbreviated version!
For detailed information about F-actin monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.225
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1.14.13.225
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plexins
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calponin
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semaphorin-plexin
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sema3a
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plexa
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semaphorin3a
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rab8
- 1.14.13.225
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plexins
- calponin
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semaphorin-plexin
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sema3a
- plexa
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semaphorin3a
- rab8
Reaction
Synonyms
MICAL, MICAL-1, MICAL-2, MICAL1, Mical2, MICAL2PV, MICAL3
ECTree
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Subunits
Subunits on EC 1.14.13.225 - F-actin monooxygenase
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additional information
human MICAL3 contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, and has an FAD/NADP-binding Rossmann-fold domain for monooxygenase activity like MICAL1, structure comparisons of isozymes MICAL3 and MICAL1. The FMO and CH domains of both isozymes MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. The catalytic efficiency of MICAL3 dramatically increases on adding F-actin only when the CH domain is available
additional information
-
human MICAL3 contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, and has an FAD/NADP-binding Rossmann-fold domain for monooxygenase activity like MICAL1, structure comparisons of isozymes MICAL3 and MICAL1. The FMO and CH domains of both isozymes MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. The catalytic efficiency of MICAL3 dramatically increases on adding F-actin only when the CH domain is available