1.14.13.182: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
This is an abbreviated version!
For detailed information about 2-heptyl-3-hydroxy-4(1H)-quinolone synthase, go to the full flat file.
Reaction
Synonyms
2-heptyl-3,4-dihydroxyquinoline synthase, Aqm, PqsH
ECTree
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Substrates Products
Substrates Products on EC 1.14.13.182 - 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
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REACTION DIAGRAM
2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
2-heptyl-1-hydroxyquinolin-4(1H)-one one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
2-heptyl-4(1H)-quinolone + NADPH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NADP+ + H2O
kcat/KM for NADH is 20fold higher than kcat/Km for NADPH
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2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
2-nonyl-4(1H)-quinolone + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons
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2-pentyl-4(1H)-quinolone + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons
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2-pentylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
2-propyl-4(1H)-quinolone + NADH + H+ + O2
3-hydroxy-2-propyl-4(1H)-quinolone + NAD+ + H2O
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons
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2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptyl-1-hydroxyquinolin-4(1H)-one one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptyl-1-hydroxyquinolin-4(1H)-one one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
PqsH catalyzes the terminal step in biosynthesis of the Pseudomonas quinolone signal molecule 2-heptyl-3-hydroxy-4(1H)-quinolone. Under anaerobic conditions 2-heptyl-3-hydroxy-4(1H)-quinolone is not produced. The enzyme is a biochemical regulator of Pseudomonas quinolone signal controlled social behaviors in Pseudomonas aeruginosa
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2-heptyl-4(1H)-quinolone + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons
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2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptylquinolin-4(1H)-one and 2-nonylquinolin-4(1H)-one, preferred substrates
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2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
preferred substrate
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2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
preferred substrate
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2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
2-heptylquinolin-4(1H)-one and 2-nonylquinolin-4(1H)-one, preferred substrates
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2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
2-heptylquinolin-4(1H)-one and 2-nonylquinolin-4(1H)-one, preferred substrates
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2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
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2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
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3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
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2-heptylquinolin-4(1H)-one and 2-nonylquinolin-4(1H)-one, preferred substrates
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2-nonylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
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2-nonylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
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2-nonylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
2-heptylquinolin-4(1H)-one and 2-nonylquinolin-4(1H)-one, preferred substrates
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2-nonylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
2-heptylquinolin-4(1H)-one and 2-nonylquinolin-4(1H)-one, preferred substrates
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2-nonylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
preferred substrate
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2-nonylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
preferred substrate
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3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
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2-pentylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
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2-pentylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
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2-pentylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
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2-pentylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
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