1.14.11.63: peptidyl-lysine (3S)-dioxygenase
This is an abbreviated version!
For detailed information about peptidyl-lysine (3S)-dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.63
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1.14.11.63
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histone
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demethylases
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trafac
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jumonji-c
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jarid2
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prdm10
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hif1an
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clipping
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gametogenesis
- 1.14.11.63
- histone
- demethylases
-
trafac
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jumonji-c
- jarid2
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prdm10
-
hif1an
-
clipping
-
gametogenesis
Reaction
Synonyms
JmjC domain-containing protein 7, JMJD7, Jumonji domain-containing protein 7
ECTree
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medicine
in head and neck squamous cell carcinoma, a read-through fusion gene JMJD7-PLA2G4B is present, splicing neighboring JMJD7 and phospholipase A2, group IVB (PLA2G4B) genes together. Ablation of JMJD7-PLA2G4B significantly inhibits proliferation of head and neck squamous cell carcinoma cells by promoting G1 cell cycle arrest and increased starvation-induced cell death compared to JMJD7-only knockdown head and neck squamous cell carcinoma cells. JMJD7-PLA2G4B modulates phosphorylation of protein kinase B to promote head and neck squamous cell carcinoma cell survival. JMJD7-PLA2G4B also regulates an E3 ligase S-phase kinase-associated protein 2 to control the cell cycle progression from G1 phase to S phase by inhibiting cyclin-dependent kinase inhibitor 1 and 1B expression