1.1.3.45: aclacinomycin-N oxidase
This is an abbreviated version!
For detailed information about aclacinomycin-N oxidase, go to the full flat file.
Word Map on EC 1.1.3.45
-
1.1.3.45
-
sirtuins
-
deacetylation
-
nad+-dependent
-
nicotinamide
-
hyperacetylation
-
mnsod
-
caloric
-
sirt3-dependent
-
longevity
-
sirt3-mediated
-
sirts
-
sirt1-7
-
foxo3a
-
acetylome
-
honokiol
- 1.1.3.45
-
sirtuins
-
deacetylation
-
nad+-dependent
- nicotinamide
-
hyperacetylation
- mnsod
-
caloric
-
sirt3-dependent
-
longevity
-
sirt3-mediated
-
sirts
-
sirt1-7
-
foxo3a
-
acetylome
- honokiol
Reaction
Synonyms
aclacinomycin oxidoreductase, AknOx, dnrW
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 1.1.3.45 - aclacinomycin-N oxidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
2 aclacinomycin A + H2O2
-
the bifunctional enzyme catalyzes the last two steps in the biosynthesis of polyketide antibiotics of the aclacinomycin group, the oxidation of the terminal sugar moiety rhodinose to cinerulose A and the oxidation of cinerulose A to L-aculose
-
-
?
2 aclacinomycin N + O2
2 aclacinomycin A + H2O2
-
bifunctional enzyme. The two different reactions of AknOx are catalyzed in the same active site but by different active site residues. Tyr450 is responsible for proton removal from the C4 hydroxyl group in the first reaction, the oxidation of rhodinose to cinerulose A. Tyr378 acts as a catalytic base involved in proton abstraction from C3 of cinerulose A in the second reaction, for formation L-aculose
-
-
?