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1.1.1.422: pseudoephedrine dehydrogenase

This is an abbreviated version!
For detailed information about pseudoephedrine dehydrogenase, go to the full flat file.

Reaction

(+)-(1S,2S)-pseudoephedrine
+
NAD+
=
(S)-2-methylamino-1-phenylpropan-1-one
 +
NADH
 +
H+

Synonyms

PseDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.422 pseudoephedrine dehydrogenase

Crystallization

Crystallization on EC 1.1.1.422 - pseudoephedrine dehydrogenase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging-drop vapor diffusion method, the crystal structure of the enzyme-NAD+ complex, refined to a resolution of 1.83 A, reveales a tetrameric structure, which is confirmed by solution studies
purified enzyme as unliganded tetramer or as monomer in complex with NAD+, X-ray diffraction structure determination and analysis at 1.83 A resolution, molecular replacement with a monomer of a gluconate 5-dehydrogenase from Thermotoga maritima (PDB ID 1VL8) used as the model
the crystal structure of the enzyme-NAD+ complex, refined to a resolution of 1.83 A, reveales a tetrameric structure, which is confirmed by solution studies