EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
   2.3.1.48 | -999 |
- |
more |
10, 25, 50 microM inhibit FLAG-tagged recombinant PCAF in vitro with an IC50 beyond 50 microM with purified human HeLa core histone as substrate |
704529 |
| 2.3.1.48 | -999 |
- |
more |
Hep-G2 hepatocarcinoma cells: with 5 microM plumbagin 50% reduction of histone H3 acetylation, with 25 microM 90% reduction, significant overall acetylation status of histones, prominent reduction in H3 and H4, immunofluorescence analysis (anti-acetylated histone H3 polyclonal antibodies) of HeLa cells (treated with deacetylase inhibitors to induce histone acetylation) confirm the inhibitory effect of plumbagin with 5 microM inhibitor, with 25 microM almost complete reduction in acetylation level |
704529 |
| 2.3.1.48 | -999 |
- |
more |
significant decrease of histone acetylation in plumbagin treated mouse liver in vivo 6 h after intraperitoneal injection of 25 mg plumbagin/kg body mass |
704529 |
| 2.3.1.48 | 0.000002 |
- |
WM-1119 |
pH and temperature not specified in the publication |
757407 |
| 2.3.1.48 | 0.0000026 |
- |
A-485 |
pH and temperature not specified in the publication |
756850 |
| 2.3.1.48 | 0.000005 |
- |
N'-(2-fluorobenzene-1-sulfonyl)-3-methoxy-5-(pyridin-2-yl)benzohydrazide |
pH and temperature not specified in the publication |
757411 |
| 2.3.1.48 | 0.0000055 |
- |
N'-(3-chloro-5-(furan-2-yl)benzoyl)-2-fluorobenzenesulfonohydrazide |
pH and temperature not specified in the publication |
757411 |
| 2.3.1.48 | 0.000006 |
- |
2-fluoro-N'-(3-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide |
pH and temperature not specified in the publication |
757411 |
| 2.3.1.48 | 0.0000063 |
- |
2-fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide |
pH and temperature not specified in the publication |
757411 |
| 2.3.1.48 | 0.000007 |
- |
2-fluoro-N'-(3-methyl-5-(3-methyl-1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide |
pH and temperature not specified in the publication |
757411 |
