EC Number   |
|---|
    1.17.1.4 | 2.1 A resolution for both xanthine oxidase and dehydrogenase forms, irreversible pancreatin cleaved xanthine oxidase form results in blocking access of substrate NAD+ to the FAD cofactor |
| 1.17.1.4 | 2.7 A resolution, direct coordination of alloxanthine to the molybdenum via a nitrogen atom |
| 1.17.1.4 | batch method, 2.5 and 3.3 A resolution for irreversible proteolytically cleaved xanthine oxidase form, 2.1 A resolution for dehydrogenase form |
| 1.17.1.4 | C535A/C992R/C1324S triple mutant XDH crystal structure analysis |
| 1.17.1.4 | crystal structure determination |
| 1.17.1.4 | crystal structure determination of the free enzyme and the enzyme in complex with inhibitor alloxanthine |
| 1.17.1.4 | high-resolution crystal structure of XDH at 1.65 A resolution confirms the overall fold of the dimeric protein, the location of the cofactors and the mobile stretches of the polypeptide chain. Crystal structures of the NAD(H) complexes of XDH reveal that, given the proper oxidation states, the nicotinamide rings of the dinucleotides locate at van der Waals distance to the flavin ring |
| 1.17.1.4 | highly active bovine XOR in its XDH form is soaked in a large excess of NADH under strictly anaerobic conditions in order to reduce both FAD cofactor and iron sulfur centers and to block any electron transfer from the Mo center. The Mo ions in the crystal are fully reduced by soaking in 4 mM titanium citrate solution followed by 0.25 mM urate, crystal structure determination and analysis, superimposition, modelling |
| 1.17.1.4 | in complex with inhibitor FYX051, which is slowly hydroxylated by the enzyme |
| 1.17.1.4 | in complex with inhibotrs allopurinol, febuxostat, and FYX-051 |
