1.13.11.81 | Y53F mutant of dihydroneopterin aldolase, Y54F mutant of dihydroneopterin aldolase |
substitution of a conserved tyrosine residue at the active site of dihydroneopterin aldolase by phenylalanine converts the enzyme to a cofactor-independent oxygenase, which generates mainly 7,8-dihydroxanthopterin rather than 6-hydroxymethyl-7,8-dihydropterin |
680350 |