EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.35 | more |
the enzyme emerged through an ancient horizontal transfer of an RNA (uracil, C5)-methyltransferase-like gene from bacteria to archaea |
Pyrococcus abyssi |
? |
- |
? |
2.1.1.35 | more |
structure-function analysis using mini-tRNA stem-loop, overview |
Pyrococcus abyssi |
? |
- |
? |
2.1.1.35 | more |
recombinant PAB0719 is shown to function like TrmA from Escherichia coli and catalyzes m5U formation at position 54 in Pyrococcus abyssi tRNAs |
Pyrococcus abyssi |
? |
- |
? |
2.1.1.35 | more |
TRMT2A commonly targets U54 of cytosolic tRNAs |
Homo sapiens |
? |
- |
- |
2.1.1.35 | more |
- |
Escherichia coli |
more |
- |
? |
2.1.1.35 | more |
not as methyl group acceptors: methyl-deficient DNA from E. coli, polyadenylic acid, polycytidylic acid, polyuridylic acid, polyinosinic acid, copolymers of adenylic acid and uridylic acid and of guanylic acid and cytidylic acid, tobacco mosaic viral RNA, turnip yellow mosaic viral RNA, RNA from bacteriophage f2, CMP, AMP, UMP, GMP, rRNA |
Escherichia coli |
more |
- |
? |
2.1.1.35 | more |
enzyme also catalyzes exchange of tritium of [3H]-Ura-16S rRNA and protons of water |
Escherichia coli |
more |
- |
? |
2.1.1.35 | more |
3 isoenzymes with different substrate specificities, also some activity with rRNA from E. coli, may be due to a contamination |
Saccharomyces cerevisiae |
more |
- |
? |
2.1.1.35 | more |
absence of TRM2 gene encoding enzyme in strains with mutant forms of tRNASerCGA decreases the stability of tRNASerCGA and induces lethality |
Saccharomyces cerevisiae |
more |
- |
? |
2.1.1.35 | more |
tetrahydrofolate derivatives as methyl group donor in the formation of 5-methyluridine |
Bacillus subtilis |
more |
- |
? |