EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.14.57 | chenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Sus scrofa |
hyocholate + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.57 | lithocholate + [reduced NADPH-hemoprotein reductase] + O2 |
activity is low compared to activity with taurochenodeoxycholate |
Sus scrofa |
hyocholate + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.57 | lithocholate + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Homo sapiens |
hyodeoxycholate + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.57 | more |
isofornm CYP3A4 is the only enzyme tested which is active towards bile acids taurochenodeoxycholate and lithocholate. The enzyme catalyzes an efficient 6alpha-hydroxylation of both taurochenodeoxycholic acid and lithocholic acid |
Homo sapiens |
? |
- |
? |
1.14.14.57 | taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Homo sapiens |
taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
1.14.14.57 | taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Sus scrofa |
taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |