EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.262 | 2-amino-3-oxo-4-phosphonooxybutyrate + H2O |
step 2 of the overall reaction |
Escherichia coli |
3-amino-1-hydroxyacetone 1-phosphate + CO2 |
i.e. AHAP |
? |
1.1.1.262 | 4-(phosphohydroxy)-L-threonine + NAD+ |
involved in pyridoxal 5'-phosphate formation |
Escherichia coli |
2-amino-3-oxo-4-phosphohydroxybutyrate + NADH |
further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate |
r |
1.1.1.262 | 4-(phosphohydroxy)-L-threonine + NAD+ |
involved in pyridoxal 5'-phosphate formation |
Escherichia coli |
2-amino-3-oxo-4-phosphohydroxybutyrate + NADH |
undergoes decarboxylation either catalysed by the enzyme or after release, further formation of pyridoxal 5'-phosphate catalysed by PdxJ protein |
r |
1.1.1.262 | 4-(phosphohydroxy)-L-threonine + NAD+ |
involved in pyridoxal 5'-phosphate formation |
Escherichia coli |
3-phosphohydroxy-1aminoacetone + CO2 + NADH + H+ |
further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate |
r |
1.1.1.262 | 4-(phosphonooxy)threonine + NAD(P)+ |
fourth step of the pyridoxal 5'-phosphate biosynthesis |
Escherichia coli |
2-amino-3-oxo-4-phosphonooxybutyrate + NAD(P)H |
- |
? |
1.1.1.262 | 4-(phosphonooxy)threonine + NAD(P)+ |
i.e. 4-hydroxy-L-threonine phosphate or HTP, enzyme strictly requires the phosphate ester form of the substrate, interaction between enzyme and substrate via phosphate group, step 1 of the overall reaction |
Escherichia coli |
2-amino-3-oxo-4-phosphonooxybutyrate + NAD(P)H |
reaction intermediate |
? |
1.1.1.262 | 4-(phosphonooxy)threonine + NAD(P)+ |
involved in the biosynthesis of vitamin B6 |
Escherichia coli |
3-amino-1-hydroxyacetone 1-phosphate + CO2 + NAD(P)H |
- |
? |
1.1.1.262 | 4-(phosphonooxy)threonine + NAD(P)+ |
i.e. 4-hydroxy-L-threonine-4-phosphate, HTP |
Escherichia coli |
3-amino-1-hydroxyacetone 1-phosphate + CO2 + NAD(P)H |
i.e. AHAB, primary product of the reaction, no formation of 2-amino-3-oxo-4-phosphonooxybutyrate as intermediate is detected, identification by electrospray ionization mass spectrometry |
? |