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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.4.1.B74physiological function characterization of a PimB MgtA double deletion mutant. Gene product of Rv2188c acts as an Ac1PIM1:mannosyltransferase PimB and the product of Rv0557 acts as a GlcAGroAc2:mannosyltransferase MgtA -, 742774
Display the reaction diagram Show all sequences 2.4.1.B74physiological function disruption of the PimB gene in a virulent strain does not abolish the production of any of its cell wall mannosylated lipoglycans but results in a quantitative decrease in the lipomannan and mannose-capped lipoarabinomannan content without affecting higher order phosphatidyl-myo-inositol mannosides. Infection of human macrophages by the PimB mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death -, 742623
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