EC Number   |
General Information |
Reference |
|---|
    2.4.1.133 | malfunction |
an antibody against beta-1,4-GalT-I attenuates both lipopolysaccharide-induced microglial activation and phagocytosis |
705941 |
| 2.4.1.133 | metabolism |
beta-1,4-galactosyltransferase 7 (beta4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan chains |
759068 |
| 2.4.1.133 | more |
mapping of the organization of the acceptor binding pockex in complex with 4-methylumbelliferone-xylopyranoside as prototype substrate by combining molecular modeling, in vitro mutagenesis, and kinetic measurements, and in cellulo analysis of glycosaminoglycan anabolism and decorin glycosylation. The organization is governed, on one side, by three tyrosine residues, Tyr194, Tyr196, and Tyr199, which create a hydrophobic environment and provide stacking interactions with both xylopyranoside and aglycone rings. On the opposite side, a hydrogen-bond network is established between the charged amino acids Asp228, Asp229, and Arg226, and the hydroxyl groups of xylose |
736498 |
| 2.4.1.133 | more |
molecular docking complex of the beta4GalT7 mutant D211N from Drosophila melanogaster with substrates naphthalen-2-yl beta-D-xylopyranoside, naphthalen-2-yl 1-thio-beta-D-xylopyranoside, 2-naphthyl 5-thio-beta-D-xylopyranoside, and 2-naphthyl 1,5-dithio-beta-D-xylopyranoside |
759068 |
| 2.4.1.133 | more |
molecular docking of substrate-bound enzyme using structures PDB ID 4LW6 and PDB ID 4M4K |
736934 |
| 2.4.1.133 | more |
the enzyme undergoes conformational changes upon substrate binding, human enzyme in its open and closed conformations, overview |
736433 |
| 2.4.1.133 | physiological function |
beta-1,4-galactosyltransferase I is a key inflammatory mediator that plays a critical role in the initiation and maintenance of inflammatory reaction in diseases, beta-1,4-GalT-I is associated with E-selectin during the pathological process of secondary response after Spinal cord injury |
704802 |
| 2.4.1.133 | physiological function |
beta-1,4-GalT I might play important roles in Schwann cells during the regeneration and degeneration of the injured sciatic nerve, enzyme plays in important role in Schwann cells in vivo and vitro during pathology, beta-1,4-GalT can catalyze the galactose from UDP-galactose to the terminal N-acetylglucosamine residues on elongating oligosaccharide chains, which are suggested to be involved in various cellular functions including cell-cell and cell-matrix interactions during embryogenesis |
704790 |
| 2.4.1.133 | physiological function |
beta-1,4-GalT-I may play an important role in adhesion and migration of Schwann cells during inflammation, enzyme is a key inflammatory mediator that participates in the initiation and maintenance of inflammatory reaction in diseases, the long beta-1,4-GalT-I isoform, due to the extra 13 amino acids at the amino-termini, is implicated in targeting the protein to cell surface, and acts as a recognition molecule associated with a variety of biological functions, including sperm-egg interactions, morula compaction, embryonic maturation, embryonal carcinoma cell spreading, neurite extension, and mesenchymal cell migration |
704010 |
| 2.4.1.133 | physiological function |
beta-1,4-GalT-I may play an important role in regulating immune cell migration into the inflammatory site and mediating microgliosis |
705941 |
