EC Number   |
General Information |
Reference |
|---|
    1.14.18.1 | evolution |
Ms1 genome scaffolds with publicly available Streptomyces genus whole genome sequences show the highest nucleotide identity (99%) with Streptomyces cyaneofuscatus strain NRRL B-2570, genes melC1 and melC2 |
745430 |
| 1.14.18.1 | evolution |
the enzyme belongs to the type-3 copper protein family |
744953 |
| 1.14.18.1 | evolution |
the primary sequence of Aspergillus niger PA2 tyrosinase has approximately 99% identity with that of Aspergillus niger CBS 513.88, phylogenetic analysis. Tyrosinase belongs to a large group of proteins termed as type-3 copper proteins |
-, 744075 |
| 1.14.18.1 | evolution |
tyrosinases and catechol oxidases (EC 1.10.3.1) are members of the class of type III copper enzymes. While tyrosinases accept both mono- and o-diphenols as substrates, only the latter substrate is converted by catechol oxidases. The distinction between mono- and diphenolase activity does not depend on the degree of restriction of the active site, and thus a more important role for amino acid residues located at the entrance to and in the second shell of the active site is proposed |
744024 |
| 1.14.18.1 | evolution |
tyrosinases are widespread in nature and act on a range of substrates |
744483 |
| 1.14.18.1 | malfunction |
after 72 h of treatment with inhibitors acetazolamide and kojic acid, acetazolamide at 0.04 mM significantly decreases the embryos pigmentation to 40.8% of untreated embryos, while kojic acid at 0.04 mM decreases only 25.0% of pigmentation. Phenotype, overview |
744671 |
| 1.14.18.1 | malfunction |
enzyme inhibition reduces melanogenesis |
744671 |
| 1.14.18.1 | malfunction |
excessive accumulation of melanin, due to the overexpression of the enzyme, leads to skin disorders such as age spots, freckles and malignant melanoma |
745819 |
| 1.14.18.1 | malfunction |
mutations in the tyrosinase gene cause oculocutaneous albinism type 1 (OCA1), an autosomal recessive disease associated with reduced melanin pigment in the hair, skin, and eyes and decreased quality of vision |
744758 |
| 1.14.18.1 | malfunction |
oculocutaneous albinism Type 1 (OCA1) is an autosomal recessive disorder caused by mutations in the tyrosinase gene. Two subtypes of OCA1 exxist, severe OCA1A with complete absence of tyrosinase activity and less severe OCA1B with residual tyrosinase activity. The recombinant OCA1A mutants expressed in insect cells show very low protein expression, protein yield, and are enzymatically inactive, while mutants mimicking OCA1B are biochemically similar to the wild-type, but exhibit lower specific activities and protein stabilities than the wild-type enzyme. OCA1A mutations inactivate tyrosinase and result in severe phenotype, while OCA1B mutations partially inactive tyrosinase and results in OCA1B albinism |
744758 |
