EC Number   |
General Information |
Reference |
|---|
   1.14.11.66 | evolution |
enzyme CG15835 shows higher identity to mammalian JMJD2D (40%) than to any of the other mammalian JMJD2 isoforms (22%) |
754921 |
| 1.14.11.66 | evolution |
enzyme CG33182 shows higher identity to mammalian JMJD2D (40%) than to any of the other mammalian JMJD2 isoforms (22%) |
754921 |
| 1.14.11.66 | evolution |
human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone, structural and phylogenetic analysis, overview. KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates, substrate selectivity of the human KDM4 histone demethylase subfamily, overview |
725450 |
| 1.14.11.66 | evolution |
JMJD2A is a JmjC histone demethylase (HDM) |
754871 |
| 1.14.11.66 | evolution |
KDM4A belongs to the KDM4 family |
753167 |
| 1.14.11.66 | evolution |
KDM4C is a member of the KDM4 subgroup of JmjC domain-containing proteins which catalyzes the demethylation of tri- and dimethylated lysine 9 and lysine 36 on histoneH3 |
745889 |
| 1.14.11.66 | evolution |
the Drosophila melanogaster HDM gene Dmel\Kdm4A is a homologue of the human JMJD2 family. Dmel\JHMD1, Dmel\JHMD2, and Dmel\Kdm4A are each highly conserved with their human homologue counterparts |
753724 |
| 1.14.11.66 | evolution |
the enzyme belongs to the family of KDM4A-D histone demethylases |
725520 |
| 1.14.11.66 | evolution |
the enzyme belongs to the Jmjd2 family of H3K9/H3K36 histone demethylases |
-, 744785 |
| 1.14.11.66 | evolution |
the enzyme belongs to the JMJD2/KDM4 subfamily (JMJD2A, B, C and D) specifically demethylates H3K9 and H3K36 either di- or trimethylated |
726259, 755066 |
