EC Number   |
Expression |
Reference |
|---|
    1.13.11.34 | down |
DNA methylation is responsible for suppression of 5-lipoxygenase expression in most cell types |
704997 |
| 1.13.11.34 | more |
5-LOX activity is quantitatively similar in normal versus Metastrongylus spp.-parasitized lung tissue samples |
712580 |
| 1.13.11.34 | more |
coexpression of the truncated natural isoforms inhibits or stimulates 5-LO-wild-type expression in transiently and stably transfected HEK-293T cells suggesting that the isoforms have other functions than canonical leukotriene biosynthesis |
742001 |
| 1.13.11.34 | up |
0.01 mM hydroxynonenal induces 5-LOX promoter activity significantly by 310% and 580% after 48 and 72 h of incubation, respectively. The addition of anti-transforming growth factor-beta1 antibody reduces hydroxynonenal-induced 5-LOX expression by 40% |
711045 |
| 1.13.11.34 | up |
aberrant methylation may lead to upregulated 5-lipoxygenase expression in tumor cells. The 5-lipoxygenase core promoter is completely methylated in cell lines U-937 and HL-60TB, which do not express 5-lipoxygenase. Treatment with the demethylating agent 5-aza-2'deoxycytidine restores 5-lipoxygenase expression |
704997 |
| 1.13.11.34 | up |
in the liver, the Alox5 mRNA expression levels significantly increase to the maximum when the dietary linolenic acid/linoleic acid increases from 0.03 to 0.06, and then significantly decreases with dietary linolenic acid/linoleic acid increased to 1.51. In the kidney, the expression levels of Alox5 of fish fed diets with low dietary linolenic acid/linoleic acid (0.03-0.06) are significantly higher than those of fish fed diets with high dietary linolenic acid/linoleic acid (0.45-1.51) |
742314 |
| 1.13.11.34 | up |
methyl-DNA binding proteins MBD1, MBD2 and MeCP2 downregulate 5-LO mRNA expression in U-937 cells |
711301 |
| 1.13.11.34 | up |
stimulation of J774A.1 cells with 0.01 mM acrolein for 4-24 h leads to increased 5-LO expression through activation of the ERK pathway. Acrolein-induced 5-LO expression is inhibited in a dose-dependent manner by pretreatment with AG1478, but not by pretreatment with AG1295 |
713540 |
