EC Number   |
Expression |
Reference |
|---|
    1.13.11.33 | up |
12/15-LO is upregulated in white adipose tissue in the obese state. The potent vasoconstricting and pro-inflammatory hormone angiotensin II (Ang II) led to increases in leukocyte-type 12-LO mRNA and protein levels, as well as increased enzyme activity |
743718 |
| 1.13.11.33 | up |
12/15-LOX activity is enhanced during chronic, but not acute, toxoplasmosis |
-, 704003 |
| 1.13.11.33 | up |
12/15-LOX mRNA expression in cultured aortic smooth muscle cells is upregulated by angiotensin II, ATII. ATII also stimulates production of LOX-derived HETEs in arterial vessels and the kidney |
742000 |
| 1.13.11.33 | up |
15LO1 is highly expressed in fresh epithelial cells from severe asthmatic patients |
728663 |
| 1.13.11.33 | up |
a sharp increase in protein expression of 12/15 lipoxygenase is found in the pancreatic islets of 10-week old db-/- obese diabetic mice compared to 8-week old counterparts |
765699 |
| 1.13.11.33 | up |
allergen challenge up-regulates the expression of 12/15-LO in airway epithelial cells in mice. Interleukin-4 and interleukin-13 are inducers |
706579 |
| 1.13.11.33 | up |
demethylation of DNA in some cell lines increases 15-LOX-1 expression. Increased levels of 15-LOX-1 are associated with downregulation of GATA-6 in Caco-2 colon cancer cells treated with sodium butyrate to induce cell differentiation and apoptosis. Activation of the cGMP-PKG system can induce the cellular expression of 15-LOX-1 in SW-480 colon cancer cells. 5-aza-2-deoxycytidine increases 15-LOX-1 expression. Interleukin-4 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines. Interleukin-13 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines |
706877 |
| 1.13.11.33 | up |
expression of 12/15-LOX pathway is upregulated in the diabetic heart |
-, 742346 |
| 1.13.11.33 | up |
hypoxia increases ALOX15 in human muscle cells |
726871 |
| 1.13.11.33 | up |
increased expression and activity of 15-LO-1 in the respiratory tissue from asthma patients. Patients with chronic obstructive pulmonary disease also display an increased expression of 15-LO-1 in bronchial biopsies. Interleukin-4 and interleukin-13 are inducers |
706579 |
