EC Number   |
Expression |
Reference |
|---|
    1.1.1.27 | down |
in the absence of sugar, SugR binds to the ldhA promoter region, thereby repressing ldhA expression. LldR also binds to the ldhA promoter region, thus negatively regulating ldhA expression. LldR is an L-lactate-responsive transcriptional repressor of L-lactate utilization genes |
712279 |
| 1.1.1.27 | down |
L-leucine depletion decreases the proteins synthesis, and also decreases L-lactate dehydrogenase B chain mRNA expression in bovine mammary alveolar cells cells |
760343 |
| 1.1.1.27 | down |
Spatholobus suberectus extract has a strong inhibitory effect on LDH-5 expression and activity inboth estrogen-dependent and estrogen-independent human breast cancer cells. Follicle-stimulating hormone, insulin, insulin-like growth factor 1, epidermal growth factor, and tumor necrosis factor alpha, are factors able to affect LDHA gene transcription through relevant intracellular signal transduction systems, including protein kinase A and C signaling pathways |
740255 |
| 1.1.1.27 | up |
deletion of water-forming NADH oxidase NOX in Streptococcus mutans leads to significantly elevated lactate dehydrogenase activity and gene ldh transcription in the DELTAnox strain, which is mediated in part by the redox-sensing regulator Rex. Rex activation of ldh transcription |
-, 740628 |
| 1.1.1.27 | up |
expression of LutACB is induced by iron-limited conditions |
-, 761650 |
| 1.1.1.27 | up |
the enzyme is induced at 37°C by 0.5 mM beta-D-thiogalactoside concentration being associated with inclusion bodies. By reducing cell growth temperature to 15°C and sopropyl beta-D-thiogalactoside concentration to 0.25 mM, it is possible to get approximately 82% of expressed protein in soluble form |
697813 |
