EC Number   |
Application |
Reference |
|---|
   2.3.1.48 | analysis |
methods for the analysis of histone acetyltransferase activity in vitro |
659855 |
| 2.3.1.48 | drug development |
HBO1 is a potential anti-cancer target, design of HBO1-targeting molecules and their applications |
756418 |
| 2.3.1.48 | drug development |
the enzyme is a unique target for therapeutic antifungal compounds |
706554 |
| 2.3.1.48 | drug development |
Tip60, the 60 kDa HIV-1 Tat-interactive protein, is a potential drug target |
735964 |
| 2.3.1.48 | medicine |
allspice hot water extract reduces androgen receptor and histone acetylation and leads to decreased transcription of androgen receptor target genes, resulting in inhibition of prostate cancer cell growth |
685667 |
| 2.3.1.48 | medicine |
CBP/p300 could be a promising therapeutic target in hepatocellular carcinoma |
736274 |
| 2.3.1.48 | medicine |
expression of isoform Tip60 is about 60% lower in samples from patients with acute myeloid leukemia |
720063 |
| 2.3.1.48 | medicine |
high mobility group domain-containing protein And-1 forms a complex with both histone H3 and isoform Gcn5. And-1 expression is increased in cancer cells in a manner correlating with increase in Gcn5 and acetylation of H3K9 and H3K56 |
720607 |
| 2.3.1.48 | medicine |
histone acetylation is significantly increased in retinas from diabetic rats, and this acetylation is inhibited in diabetics treated with minocycline. Both the acetylation and induction of the inflammatory proteins in elevated glucose levels are significantly inhibited by inhibitors of histone acetyltransferase, such as garcinol and antisense against the histone acetylase, p300, or activators of histone deacetylase, such as theophylline and resveratrol, and are increased by the histone deacetylase inhibitor, suberolylanilide hydroxamic acid. Hyperglycemia causes acetylation of retinal histones and probably other proteins and the acetylation contributes to the hyperglycemia-induced upregulation of proinflammatory proteins and thereby to the development of diabetic retinopathy |
720032 |
| 2.3.1.48 | medicine |
pathogenesis of late-onset Alzheimer disease, post-translational regulation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) levels, a membrane protein that acts as the rate-limiting enzyme in the generation of Alzheimer disease amyloid beta-peptide, acetylation protect the protein from degradation |
704532 |
