EC Number   |
Application |
Reference |
|---|
    2.1.1.37 | analysis |
synthesis of acyclic nucleosides containing a 5-fluorouracil nucleobase, FC-ac1, and FC-ac2 to study the reaction mechanism. The oligodeoxynucleotides containing ODN-FC-ac1 and ODN-FC-ac2 show an increased flexiblilty. A negative correlation is observed between the flexibility and ODN-DNMT complex formation. A weaker nucleobase stacking effect due to the increase in flexibility at the acyclic modification site may provide a higher flip out effect, while the local flexibility would influence the scanning and recognition steps |
756190 |
| 2.1.1.37 | biotechnology |
using a truncated and highly active form of human DNMT1 and a designed hemimethylated DNA substrate, a robust, efficient, and economical fluorescence assay is developped suitable for in vitro high-throughput screening of DNMT1 |
718565 |
| 2.1.1.37 | drug development |
Dnmt inhibition is a promising strategy for the treatment of various developmental and proliferative diseases, particularly cancers |
703228 |
