EC Number   |
Application |
Reference |
|---|
   1.3.1.20 | diagnostics |
overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients, patients with DDH overexpression have a significantly higher incidence of early tumor recurrence and distant metastasis |
697571 |
| 1.3.1.20 | medicine |
enzyme can be used for screening of antiinflammatory potency of drugs |
349257 |
| 1.3.1.20 | medicine |
enzyme is expressed in a high percentage of primary ovarian tumors and may be associated with cisplatin-based chemotherapy resistance |
673903 |
| 1.3.1.20 | medicine |
enzyme may play an important role in benz[a]pyrene carcinogenesis via oxidative DNA damage |
655236 |
| 1.3.1.20 | medicine |
enzyme overexpression is detected in 66.9% of pathological sections and in 41.6% of metastatic lymph nodes in patients with esophageal squamous cell carcinoma, the major isoform is DDH2. Enzyme overexpression is positively correlated with smoking habit, tumor stage, number of metastatic lymph nodes, lymphovascular invasion and COX-2 expression, and inversely correlated with glutathione-S-transferase and nm23-HI expression. Patients with low enzyme expression have significantly lower incidence of tumor recurrences and better survival |
655744 |
| 1.3.1.20 | medicine |
expression of enzyme isoforms 1 and 2 is detected in 59.6% of pathologicla sections, enzyme expression is significantly higher in patients with tumor size over 2 cm, an in those who had early local recurrence. enzyme expression correlates with those of COX-2, interleukin-6, microsomal epoxide hydrolase and soluble epoxide hydrolase in patients. It is inversely correlated with expression of glutathione S-transferase and NADPH p450 reductase |
656885 |
| 1.3.1.20 | medicine |
high expression level of enzyme in A431 squamous cell carcinoma, which is barely detectable in other normal or malignant cutaneous cells, including keratinocytes |
675089 |
| 1.3.1.20 | medicine |
reduction of enzyme expression in lung tumors may contribute to an increase in DNA adduct levels and may partly be responsible for the higher susceptibility of female lung cancer patients to DNA damage. Detection of DNA adducts correlates with CYP1A1-positive tumors, but not with isoform DDH1-positive tumors |
673371 |
| 1.3.1.20 | medicine |
resistance to doxorubicin and cisplatin in lung adenocarcinoma cell lines is closely associated with enzyme isoforms DDH1 and DDH2 activity |
671358 |
