EC Number   |
Application |
Reference |
|---|
    1.17.1.4 | agriculture |
treatment of normal fruit in linear phase of growth with enzyme inhibitors allopurinol or adenine arrests fruit growth |
656630 |
| 1.17.1.4 | analysis |
use of rosy mutant strains to probe structure and function of xanthine dehydrogenase |
644578 |
| 1.17.1.4 | biotechnology |
the enzyme can be useful in biotechnlogical applications requiring special conditions, e.g. extreme pH values |
744450 |
| 1.17.1.4 | environmental protection |
XDHs can find applications in environmental degradation of pollutants like aldehydes and industrial application in nucleoside drugs like ribavirin |
-, 744450 |
| 1.17.1.4 | medicine |
cocaine-induced cardiac disfunction is associated with an increase in NADPH oxidase and xanthine oxidoreductase activities by 59% and 29%, respectively, and a decrease in catalase activity. Apocynin or allopurinol treatment prevents the cocaine-induced cardiac alteration by restoration of cardiac output, stroke volume and fractional shortening. This is associated with a reduction of the myocardial production of superoxide anions and an enhancement of catalase activity. Apocynin treatment prevents anthine oxidoreductase up-regulation supporting the hypothesis that NADPH oxidase-derived reactive oxygen species play a role in modulating reactive oxygen species production by xanthine oxidoreductase |
688448 |
| 1.17.1.4 | medicine |
demonstration of a functional link between xanthine oxidoreductase expression and mammary epithelial cell migration, potential role in enzyme in suppressing breast cancer pathogenesis. Level of xanthine oxidoreductase is markedly reduced in highly invasive mammary tumor cells, and over-expression of enzyme cDNA in cell lines possessing weak expression and high migratory capacity inhibits their migration in vitro |
687917 |
| 1.17.1.4 | medicine |
demonstration of a functional link between xanthine oxidoreductase expression and mammary epithelial cell migration, potential role in enzyme in suppressing breast cancer pathogenesis. Over-expression of enzyme cDNA in cell lines possessing weak expression and high migratory capacity inhibits their migration in vitro |
687917 |
| 1.17.1.4 | medicine |
enzyme null mutant mice demonstrate 50% reduction in adipose mass compared to control, while obese mice exhibit increased concentrations of xanthine oxidoreductase mRNA and urate in adipose tissues. In vitro, knockdown of xanthine oxidoreductase inhibits adipogenesis and nuclear receptor PPARgamma activity. Xanthine oxidoreductase is a potential therapeutic target for metabolic abnormalities beyond hyperuricemia |
672979 |
| 1.17.1.4 | medicine |
lung xanthine oxidoreductase activity is significantly increased after 2 h of mechanical ventilation without changes in enzyme expression. Increase occurs via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with ventilator-induced lung injury |
671254 |
| 1.17.1.4 | medicine |
modification of xanthine oxidoreductase by disulfiram that is used in the management of chronic alcolism |
644600 |
