EC Number   |
Application |
Reference |
|---|
    1.1.1.27 | agriculture |
L-leucine depletion decreases the proteins synthesis, and also decreases L-lactate dehydrogenase B chain mRNA expression in bovine mammary alveolar cells |
760343 |
| 1.1.1.27 | analysis |
construction of multiplexed direct electron transfer-type lactate and glucose sensors using a fusion enzyme between L-lactate oxidase from Aerococcus viridans, A96L/N212K mutant, which is minimized in its oxidase activity and b-type cytochrome protein. The sensors achieve simultaneous detection of lactate and glucose without cross-talking error, with the detected linear ranges of 0.5-20 mM for lactate and 0.1-5 mM for glucose, sensitivities of 4.1 nA/mM x mm2 for lactate and 56 nA/mM x mm2 for glucose, and limit of detections of 0.41 mM for lactate and 0.057 mM for glucose |
760746 |
| 1.1.1.27 | analysis |
CpLDH with APAD+ may be useful as a diagnostic tool for detection of protozoan parasite Cryptosporidium |
740541 |
| 1.1.1.27 | analysis |
reproducible and validated LDH assay optimized for several cell types for application in clinical medicine and biomedical sciences. Assay is cost effective and allows for experiment-specific optimization |
760946 |
| 1.1.1.27 | biotechnology |
a chimeric bifunctional enzyme composing of galactose dehydrogenase from Pseudomonas fluorescens and lactate dehydrogenase from Bacillus stearothermophilus is successfully constructed. The chimeric enzyme is able to recycle NAD with a continuous production of lactate without any externally added NADH |
668976 |
| 1.1.1.27 | biotechnology |
genetic tools for use in Clostridium thermocellum that allow creation of unmarked mutations while using a replicating plasmid. The strategy employs counter-selections developed from the native C. thermocellum hpt gene and the Thermoanaerobacterium saccharolyticum tdk gene and is used to delete the genes for both lactate dehydrogenase (Ldh) and phosphotransacetylase (Pta) |
-, 735482 |
| 1.1.1.27 | degradation |
direct conversion of switchgrass to ethanol without conventional pretreatment of the biomass is accomplished by deletion of lactate dehydrogenase and heterologous expression of a Clostridium thermocellum bifunctional acetaldehyde/alcohol dehydrogenase. Whereas wild-type Caldicellulosiruptor bescii lacks the ability to make ethanol, 70% of the fermentation products in the engineered strain are ethanol (12.8 mM ethanol directly from 2% wt/vol switchgrass) with decreased production of acetate by 38% compared with wild-type |
-, 737166 |
| 1.1.1.27 | diagnostics |
LDH levels might serve as a significant prognostic factor in high-risk patients with metastatic renal cell carcinoma (RCC) and a predictive factor associated with the response and survival benefit of the mTOR complex-1 (mTORC1) inhibitor temsirolimus. LDH is one of the risk factors included in the international prognostic index (IPI) and it is considered a strong predictor of survival of patients with aggressive lymphoid cancers. Serum LDH level inversely correlates with the survival of patients with small cell lung cancer (SCLC) and allows the selection of very high-risk patients. Serum LDH might be a useful marker for predicting global clinical outcomes in hepatocellular carcinoma patients treated with a tyrosine kinase inhibitor (sorafenib). The determination of serum LDH levels appears to be a helpful clinical tool also in the diagnosis of prostate cancer and in the control of androgenic treatment |
740255 |
| 1.1.1.27 | diagnostics |
low LDH affinity kinetics can be a diagnostic parameter for human breast cancer |
740253 |
| 1.1.1.27 | diagnostics |
the enzyme is useful as marker for endometrial carcinoma |
683562 |
