EC Number   |
Inhibitors |
Structure |
|---|
    1.17.1.4 | 1-methylhypoxanthine |
17% inhibition of xanthine dehydrogenase at 0.25 mM |
   |
| 1.17.1.4 | 17beta-estradiol |
inhibition of enzyme activity in malignant and non-malignant mammary epithelial cells |
|
| 1.17.1.4 | 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid |
i.e. TEI-6720, mixed type inhibitor, binds very tightly to active and inactive desulfo-form of enzyme |
|
| 1.17.1.4 | 2-amino-4-hydroxypteridine-6-carboxyaldehyde |
competitive inhibition of 2-amino-4-hydoxy-pterine oxidation, Ki: 0.000016 mM |
|
| 1.17.1.4 | 2-amino-4-hydroxypteridine-6-carboxyaldehyde |
competitive inhibition of 2-amino-4-hydroxy-pterine oxidation, Ki: 0.00025 mM, non-competitive inhibition of xanthine oxidation, Ki: 0.00051 mM |
|
| 1.17.1.4 | 2-amino-4-hydroxypterin |
substrate inhibition above 0.01 mM |
|
| 1.17.1.4 | 2-Iodosobenzoic acid |
50% inhibition at 0.0025 mM of NAD+-dependent activity by enzyme inactivation, not by conversion to the O2-dependent activity |
|
| 1.17.1.4 | 2-Iodosobenzoic acid |
effective inhibition of xanthine and pterine oxidation |
|
| 1.17.1.4 | 4-(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyridine-2-carbonitrile |
i.e. FYX-051, strong, in absence of xanthine slow hydroxylation of inhibitor |
|
| 1.17.1.4 | 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile |
i.e. FYX-051, inhibition of xanthine oxidoreductase. In vivo, the inhibitor is modified by N1- and N2-glucuronidation, mainly catalyzed by UDP-glucuronosyltransferase UGT1A9 |
|
