EC Number   |
Activating Compound |
Reference |
|---|
   2.3.1.48 | (3E,5E)-1-ethyl-3,5-bis[(4-hydroxy-3-nitrophenyl)methylidene]piperidin-4-one |
128% activity at 0.1 mM |
756479 |
| 2.3.1.48 | (3E,5E)-3,5-bis[(3,4-dihydroxyphenyl)methylidene]piperidin-4-one |
114% activity at 0.1 mM |
756479 |
| 2.3.1.48 | 2-chloro-4-trifluoromethyl benzamide |
activates the enzyme, the relative position of the -CF3 and -Cl is crucial for p300 HAT activity enhancement, overview |
675618 |
| 2.3.1.48 | 2-dodecylmalonate |
compound induces hyperacetylation of specific lysine residues of histone H3, in particular residues K9 and K18, and raises the level of pan-acetylated H4. Compound inhibits the acetylation of all the other H3 and H4 lysines, with the exception of residue K8Ac of histone H4 |
719084 |
| 2.3.1.48 | 4-chloro-2-trifluoromethyl benzamide |
activates the enzyme, the relative position of the -CF3 and -Cl is crucial for p300 HAT activity enhancement, overview |
675618 |
| 2.3.1.48 | Asf1 |
- |
756850 |
| 2.3.1.48 | Asf1 |
a histone chaperone that activates the enzyme |
705685 |
| 2.3.1.48 | bleomycin |
activation of the ATM-associated enzyme by bleomycin, the free, non-ATM-associated, Tip60 activity is not activated by bleomycin |
676776 |
| 2.3.1.48 | BRPF2 |
a short N-terminal region of BRPF2 (residues 31-80) is sufficient for binding to the enzyme and can potentiate its activity toward [histone H3]-L-lysine14 |
757845 |
| 2.3.1.48 | BRPF2 |
i.e. BRD1, BRPF2 is a cofactor directing HBO1 binding to the histone and binds to HBO1 in a cervical-loop structure proximity to the MYST domain to facilitate histone binding |
756418 |
