Application | Comment | Organism |
---|---|---|
medicine | infection of human macrophages by a PimB gene disruption mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WMZ3 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WMZ3 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PimB | - |
Mycobacterium tuberculosis |
Rv0557 | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | disruption of the PimB gene in a virulent strain does not abolish the production of any of its cell wall mannosylated lipoglycans but results in a quantitative decrease in the lipomannan and mannose-capped lipoarabinomannan content without affecting higher order phosphatidyl-myo-inositol mannosides. Infection of human macrophages by the PimB mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death | Mycobacterium tuberculosis |