Literature summary for 2.4.1.41 extracted from

Yan, X.; Lu, J.; Zou, X.; Zhang, S.; Cui, Y.; Zhou, L.; Liu, F.; Shan, A.; Lu, J.; Zheng, M.; Feng, B.; Zhang, Y.
The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation (2018), FEBS J., 285, 3041-3055 .

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Application

Application	Comment	Organism
medicine	isoform GalNAc-T4 shows a stage-dependent expression at the different stages of colorectal cancer in 62 pair-matched tumor/normal tissues. GalNAc-T4 expression is significantly induced at stage I and II but not at stage III and IV. Overexpression of GalNAc-T4 in colorectal cancer cells enhances colony formation and sphere formation. Knockdown of GalNAc-T4 in colorectal cancer cells increases the cell migration and invasion, and leads to an epithelial-mesenchymal transition-like transition. Loss of GalNAc-T4 contributes to the dedifferentiation of colorectal cancer cells and high expression of GalNAc-T4 correlates to a good prognosis of patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N4A0	isoform GALNT4	-

Synonyms

Synonyms	Comment	Organism
Galnt4	-	Homo sapiens

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Release 2023.1 (January 2023)