Protein Variants | Comment | Organism |
---|---|---|
H253D | catalytically dead Mn2+ binding site mutant | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | predominant localization | Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6P9A2 | isoform Galnt18 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | full length GalNAc-T18 carries high-mannose N-glycan | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
PC-12 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GalNAc-T18 | - |
Homo sapiens |
Galnt18 | - |
Homo sapiens |
NM_001079884 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | GalNAc-T18 silencing in cells decreases O-glycosylation levels and activates ER stress leading to apoptosis. After treatment with chaperone 4-phenylbutyric acid or forced expression of GalNAc-T18 in the GalNAc-T18 knockdown cell, these defects can be significantly alleviated. GalNAc-T18 exerts its functions in O-glycosylation and ER stress via a non-catalytic mechanism. Both wild-type GalNT18 and mutant H253D show no catalytic activity in vitro, but both of them can rescue the O-glycosylation defect of GalNAc-T18 knockdown cells | Homo sapiens |